VUF-10497

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555207

CAS#: 1080623-12-6

Description: VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 also possesses considerable affinity for the human histamine H(1) receptor (H(1)R) and therefore represent a novel class of dual action H(1)R/H(4)R ligands, a profile that potentially leads to added therapeutic benefit. VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat.

Chemical Structure

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VUF-10497
CAS# 1080623-12-6
Instruction

Theoretical Analysis

MedKoo Cat#: 555207
Name: VUF-10497
CAS#: 1080623-12-6
Chemical Formula: C18H20ClN5S
Exact Mass: 373.11
Molecular Weight: 373.903
Elemental Analysis: C, 57.82; H, 5.39; Cl, 9.48; N, 18.73; S, 8.57

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VUF-10497; VUF 10497; VUF10497.

IUPAC/Chemical Name: 6-chloro-2-(4-methylpiperazin-1-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine

InChi Key: OLJSGKYQYTWQNJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H20ClN5S/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)

SMILES Code: CN1CCN(C2=NC(NCC3=CC=CS3)=C4C=C(Cl)C=CC4=N2)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 373.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Smits RA, de Esch IJ, Zuiderveld OP, Broeker J, Sansuk K, Guaita E, Coruzzi G,
Adami M, Haaksma E, Leurs R. Discovery of quinazolines as histamine H4 receptor
inverse agonists using a scaffold hopping approach. J Med Chem. 2008 Dec
25;51(24):7855-65. doi: 10.1021/jm800876b. PubMed PMID: 19053770.