VUF-10214

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555205

CAS#: 848837-33-2

Description: VUF-10214 is a H4 receptor-ligand. In vivo studies in the rat reveal that VUF-10214 has significant anti-inflammatory properties in the carrageenan-induced paw-edema model.


Chemical Structure

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VUF-10214
CAS# 848837-33-2

Theoretical Analysis

MedKoo Cat#: 555205
Name: VUF-10214
CAS#: 848837-33-2
Chemical Formula: C13H14Cl2N4O
Exact Mass: 312.05
Molecular Weight: 313.182
Elemental Analysis: C, 49.86; H, 4.51; Cl, 22.64; N, 17.89; O, 5.11

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: VUF-10214; VUF 10214; VUF10214.

IUPAC/Chemical Name: 6,7-dichloro 3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one

InChi Key: MFJVHWQDKIEBCM-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H14Cl2N4O/c1-18-2-4-19(5-3-18)12-13(20)17-11-7-9(15)8(14)6-10(11)16-12/h6-7H,2-5H2,1H3,(H,17,20)

SMILES Code: O=C1NC2=C(C=C(Cl)C(Cl)=C2)N=C1N3CCN(C)CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 313.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pozzoli C, Adami M, Smits RA, Coruzzi G. Effect of histamine H4 receptor
ligands on cholinergic neurotransmission of the rat duodenum. Inflamm Res. 2009
Apr;58 Suppl 1:59-60. doi: 10.1007/s00011-009-2012-4. PubMed PMID: 19271139.


2: Smits RA, Lim HD, Hanzer A, Zuiderveld OP, Guaita E, Adami M, Coruzzi G, Leurs
R, de Esch IJ. Fragment based design of new H4 receptor-ligands with
anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51(8):2457-67. doi:
10.1021/jm7014217. Epub 2008 Mar 22. PubMed PMID: 18357976.