LASSBio-1359

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562402

CAS#: 1396397-19-5

Description: LASSBio-1359 is an adenosine receptor agonist. It acts by inducing relaxation of corpus cavernosum. It is also acts as a novel selective phosphodiesterase-.

Chemical Structure

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LASSBio-1359
CAS# 1396397-19-5
Instruction

Theoretical Analysis

MedKoo Cat#: 562402
Name: LASSBio-1359
CAS#: 1396397-19-5
Chemical Formula: C17H18N2O3
Exact Mass: 298.13
Molecular Weight: 298.340
Elemental Analysis: C, 68.44; H, 6.08; N, 9.39; O, 16.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: LASSBio-1359; LASSBio 1359; LASSBio1359;

IUPAC/Chemical Name: Benzoic acid, (2E)-2-[(3,4-dimethoxyphenyl)methylene]-1-methylhydrazide

InChi Key: ZKKIMIBBUMDNHP-LDADJPATSA-N

InChi Code: InChI=1S/C17H18N2O3/c1-19(17(20)14-7-5-4-6-8-14)18-12-13-9-10-15(21-2)16(11-13)22-3/h4-12H,1-3H3/b18-12+

SMILES Code: O=C(N(C)/N=C/C1=CC=C(OC)C(OC)=C1)C2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 298.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Montes GC, Hammes N, da Rocha MD, Montagnoli TL, Fraga CA, Barreiro EJ, Sudo RT, Zapata-Sudo G. Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation. J Pharmacol Exp Ther. 2016 Aug;358(2):315-23. doi: 10.1124/jpet.115.231241. Epub 2016 May 18. PubMed PMID: 27194479.

2: Moura VJ, Alencar AK, Calasans-Maia Jde A, da Silva JS, Fraga CA, Zapata-Sudo G, Barreiro EJ, Sudo RT. Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study. Urology. 2015 May;85(5):1214.e17-21. doi: 10.1016/j.urology.2015.02.006. PubMed PMID: 25917739.

3: Alencar AK, Pereira SL, Montagnoli TL, Maia RC, Kümmerle AE, Landgraf SS, Caruso-Neves C, Ferraz EB, Tesch R, Nascimento JH, de Sant'Anna CM, Fraga CA, Barreiro EJ, Sudo RT, Zapata-Sudo G. Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline-induced pulmonary hypertension in rats. Br J Pharmacol. 2013 Jul;169(5):953-62. doi: 10.1111/bph.12193. PubMed PMID: 23530610; PubMed Central PMCID: PMC3696320.