ACS67 | CAS# 1088434-86-9 | Neuroprotectant

ACS67
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571531

CAS#: 1088434-86-9

Description: ACS67 is an F-series prostaglandin (PG) analog for treatment of glaucoma. ACS 67 reduces intra-ocular pressure (IOP) and increases levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits. ACS67 also acts as a neuroprotectant that stimulates GSH levels.

Chemical Structure

ACS67

CAS# 1088434-86-9

Instruction

Theoretical Analysis

MedKoo Cat#: 571531
Name: ACS67
CAS#: 1088434-86-9
Chemical Formula: C32H38O5S3
Exact Mass: 598.19
Molecular Weight: 598.830
Elemental Analysis: C, 64.18; H, 6.40; O, 13.36; S, 16.06

Price and Availability

Size	Price	Availability
1mg	USD 450	2 Weeks
5mg	USD 750	2 Weeks
10mg	USD 1350	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: ACS67; ACS-67; ACS 67

IUPAC/Chemical Name: 5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, (5Z)-

InChi Key: JEEWZRQQYWVJCX-WEWVERJPSA-N

InChi Code: InChI=1S/C32H38O5S3/c33-24(15-12-22-8-4-3-5-9-22)16-19-27-26(28(34)20-29(27)35)10-6-1-2-7-11-31(36)37-25-17-13-23(14-18-25)30-21-32(38)40-39-30/h1,3-6,8-9,13-14,17-18,21,24,26-29,33-35H,2,7,10-12,15-16,19-20H2/b6-1-/t24-,26+,27+,28-,29+/m0/s1

SMILES Code: O=C(OC1=CC=C(C(SS2)=CC2=S)C=C1)CCC/C=C\C[C@@H]3[C@@H](CC[C@@H](O)CCC4=CC=CC=C4)[C@H](O)C[C@@H]3O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 598.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Osborne NN, Ji D, Abdul Majid AS, Fawcett RJ, Sparatore A, Del Soldato P. ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):284-94. doi: 10.1167/iovs.09-3999. Epub 2009 Aug 26. PMID: 19710416.

2: Salvi A, Bankhele P, Jamil J, Chitnis MK, Njie-Mbye YF, Ohia SE, Opere CA. Effect of Hydrogen Sulfide Donors on Intraocular Pressure in Rabbits. J Ocul Pharmacol Ther. 2016 Jul-Aug;32(6):371-5. doi: 10.1089/jop.2015.0144. Epub 2016 Apr 19. PMID: 27092593; PMCID: PMC4960495.

3: Olas B. Medical Functions of Hydrogen Sulfide. Adv Clin Chem. 2016;74:195-210. doi: 10.1016/bs.acc.2015.12.007. Epub 2016 Mar 9. PMID: 27117664.

4: Salvi A, Bankhele P, Jamil JM, Kulkarni-Chitnis M, Njie-Mbye YF, Ohia SE, Opere CA. Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro. Neurochem Res. 2016 May;41(5):1020-8. doi: 10.1007/s11064-015-1784-x. Epub 2015 Dec 23. PMID: 26700431.

5: Tang G, Zhang L, Yang G, Wu L, Wang R. Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells. Diabetologia. 2013 Mar;56(3):533-41. doi: 10.1007/s00125-012-2806-8. Epub 2012 Dec 30. PMID: 23275972.

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ACS67 featured