DABTH

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581159

CAS#: 72683-57-9

Description: DABTH


Chemical Structure

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DABTH
CAS# 72683-57-9

Theoretical Analysis

MedKoo Cat#: 581159
Name: DABTH
CAS#: 72683-57-9
Chemical Formula: C17H17N5OS
Exact Mass: 339.1154
Molecular Weight: 339.42
Elemental Analysis: C, 60.16; H, 5.05; N, 20.63; O, 4.71; S, 9.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DABTH

IUPAC/Chemical Name: 4-Imidazolidinone, 3-(4-((4-(dimethylamino)phenyl)azo)phenyl)-2-thioxo-

InChi Key: VETMUHWKWZQFEY-FMQUCBEESA-N

InChi Code: InChI=1S/C17H17N5OS/c1-21(2)14-7-3-12(4-8-14)19-20-13-5-9-15(10-6-13)22-16(23)11-18-17(22)24/h3-10H,11H2,1-2H3,(H,18,24)/b20-19+

SMILES Code: O=C(CN1)N(C2=CC=C(/N=N/C3=CC=C(N(C)C)C=C3)C=C2)C1=S

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 339.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Stocchi V, Piccoli G, Magnani M, Palma F, Biagiarelli B, Cucchiarini L. Reversed-phase high-performance liquid chromatography separation of dimethylaminoazobenzene sulfonyl- and dimethylaminoazobenzene thiohydantoin-amino acid derivatives for amino acid analysis and microsequencing studies at the picomole level. Anal Biochem. 1989 Apr;178(1):107-17. PubMed PMID: 2499218.

2: Wilson KJ, Rodger K, Hughes GJ. Microsequence analyses: II. DABTH-amino acid identification by high-performance liquid and thin-layer chromatography. FEBS Lett. 1979 Dec 1;108(1):87-91. PubMed PMID: 118054.

3: Lu HS, Gracy RW. Solid-phase protein and peptide sequencing using either 4-N,N-dimethylaminoazobenzene 4'-isothiocyanate or phenylisothiocyanate. Arch Biochem Biophys. 1984 Nov 15;235(1):48-62. PubMed PMID: 6437338.

4: Yang CY, Wakil SJ. Separation of dimethylaminoazobenzenethiohydantoin amino acids by high-performance liquid chromatography at low picomole concentrations. Anal Biochem. 1984 Feb;137(1):54-7. PubMed PMID: 6428264.

5: Chang JY, Tran TH. Antithrombin III Basel. Identification of a Pro-Leu substitution in a hereditary abnormal antithrombin with impaired heparin cofactor activity. J Biol Chem. 1986 Jan 25;261(3):1174-6. PubMed PMID: 3080419.

6: Salvà M, Avilés FX. Improvements in the application of the 4,4-N,N-dimethylaminoazobenzene-4'-isothiocyanate micromethod to the sequence analysis of proteins. Anal Biochem. 1989 Aug 1;180(2):374-9. PubMed PMID: 2510547.

7: Marriq C, Rolland M, Lissitzky S. Identification of iodotyrosines and some iodothyronines as dimethylaminoazobenzenethiohydantoin derivatives. Application to the sequencing of iodoamino acid containing peptides. Anal Biochem. 1981 Sep 1;116(1):89-92. PubMed PMID: 6795969.

8: Fischer PM, Howden ME. Analysis of 4-N,N-dimethylaminoazobenzene 4'-thiohydantoin amino acids at sub-picomole levels by high-performance liquid chromatography: simultaneous manual sequencing of picomole quantities of several polypeptides. Anal Biochem. 1989 Feb 15;177(1):46-9. PubMed PMID: 2500874.

9: Chang JY. N-terminal sequence analysis of polypeptide at the picomole level. Biochem J. 1981 Dec 1;199(3):557-64. PubMed PMID: 6803770; PubMed Central PMCID: PMC1163410.