Tyrphostin 1
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562361

CAS#: 2826-26-8

Description: Tyrphostin 1 is an EGFR tyrosine kinase inhibitor.


Chemical Structure

img
Tyrphostin 1
CAS# 2826-26-8

Theoretical Analysis

MedKoo Cat#: 562361
Name: Tyrphostin 1
CAS#: 2826-26-8
Chemical Formula: C11H8N2O
Exact Mass: 184.0637
Molecular Weight: 184.19
Elemental Analysis: C, 71.73; H, 4.38; N, 15.21; O, 8.69

Price and Availability

Size Price Availability Quantity
25.0mg USD 350.0 2 Weeks
Bulk inquiry

Synonym: Tyrphostin 1; Tyrphostin-1; Tyrphostin1;

IUPAC/Chemical Name: 2-[(4-Methoxyphenyl)methylidene]propanedinitrile

InChi Key: UOHFCPXBKJPCAD-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3

SMILES Code: N#C/C(C#N)=C/C1=CC=C(OC)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 184.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Corrêa Gde R, Cunha KC, dos Santos AA, de Araujo EG. The trophic effect of ouabain on retinal ganglion cell is mediated by EGF receptor and PKC delta activation. Neurochem Res. 2010 Sep;35(9):1343-52. doi: 10.1007/s11064-010-0190-7. Epub 2010 May 25. PubMed PMID: 20499167.

2: Odell LR, Chau N, Mariana A, Graham ME, Robinson PJ, McCluskey A. Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase. ChemMedChem. 2009 Jul;4(7):1182-8. doi: 10.1002/cmdc.200900054. PubMed PMID: 19437476.

3: Kim SJ, Nam YR, Shin O, Choi J, Lee B, Chang JW, Kwon YK, Park K, Lee H. Treatment with hydroxyurea and tyrphostin-1 significantly improves the transduction efficiency of recombinant adeno-associated viruses in human cancer cells. Oncol Rep. 2005 Dec;14(6):1475-9. PubMed PMID: 16273241.

4: Sugano E, Tomita H, Ishiguro S, Abe T, Tamai M. Establishment of effective methods for transducing genes into iris pigment epithelial cells by using adeno-associated virus type 2. Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3341-8. PubMed PMID: 16123438.

5: Reistad T, Mariussen E. A commercial mixture of the brominated flame retardant pentabrominated diphenyl ether (DE-71) induces respiratory burst in human neutrophil granulocytes in vitro. Toxicol Sci. 2005 Sep;87(1):57-65. Epub 2005 Jun 15. PubMed PMID: 15958660.

6: Smith AD, Collaco RF, Trempe JP. Enhancement of recombinant adeno-associated virus type 2-mediated transgene expression in a lung epithelial cell line by inhibition of the epidermal growth factor receptor. J Virol. 2003 Jun;77(11):6394-404. PubMed PMID: 12743297; PubMed Central PMCID: PMC155027.

7: Tsukagoshi H, Kawata T, Shimizu Y, Ishizuka T, Dobashi K, Mori M. 4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway. Toxicol Appl Pharmacol. 2002 Nov 1;184(3):127-35. PubMed PMID: 12460740.

8: Rattan S, Fan YP, Puri RN. Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles. Life Sci. 2002 Mar 22;70(18):2147-64. PubMed PMID: 12002807.

9: Wang GF, Zhu YL, Chen JK, Zhang WH, Zhong YQ, Hu YZ, Wang FZ. [Interleukin-2 stimulates the proliferation of cultured RC-4B/C pituitary adenoma cell line]. Sheng Li Xue Bao. 2000 Jun;52(3):188-92. Chinese. PubMed PMID: 11956561.

10: Munaron L, Fiorio Pla A. Calcium influx induced by activation of tyrosine kinase receptors in cultured bovine aortic endothelial cells. J Cell Physiol. 2000 Dec;185(3):454-63. PubMed PMID: 11056017.

11: Favoreel HW, Nauwynck HJ, Van Oostveldt P, Pensaert MB. Role of anti-gB and -gD antibodies in antibody-induced endocytosis of viral and cellular cell surface glycoproteins expressed on pseudorabies virus-infected monocytes. Virology. 2000 Feb 15;267(2):151-8. PubMed PMID: 10662611.

12: Mongin AA, Reddi JM, Charniga C, Kimelberg HK. [3H]taurine and D-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Am J Physiol. 1999 May;276(5 Pt 1):C1226-30. PubMed PMID: 10329972.

13: Standley PR, Obards TJ, Martina CL. Cyclic stretch regulates autocrine IGF-I in vascular smooth muscle cells: implications in vascular hyperplasia. Am J Physiol. 1999 Apr;276(4 Pt 1):E697-705. PubMed PMID: 10198306.

14: Tchorzewski MT, Qureshi FG, Duncan MD, Duncan KL, Saini N, Harmon JW. Role of insulin-like growth factor-I in esophageal mucosal healing processes. J Lab Clin Med. 1998 Aug;132(2):134-41. PubMed PMID: 9708574.

15: Liu M, Liu J, Buch S, Tanswell AK, Post M. Antisense oligonucleotides for PDGF-B and its receptor inhibit mechanical strain-induced fetal lung cell growth. Am J Physiol. 1995 Aug;269(2 Pt 1):L178-84. PubMed PMID: 7653578.

16: White JR, Lee JC. Effect of protein kinase inhibitors on IL-8/NAP-1 release from human umbilical vein endothelial cells. Agents Actions. 1993;39 Spec No:C73-6. PubMed PMID: 8273591.

17: Wijetunge S, Aalkjaer C, Schachter M, Hughes AD. Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells. Biochem Biophys Res Commun. 1992 Dec 30;189(3):1620-3. PubMed PMID: 1336377.

18: Pumiglia KM, Lau LF, Huang CK, Burroughs S, Feinstein MB. Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). Biochem J. 1992 Sep 1;286 ( Pt 2):441-9. PubMed PMID: 1530576; PubMed Central PMCID: PMC1132918.