UC-112
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562355

CAS#: 383392-66-3

Description: UC-112 is an IAP inhibitor. It acts by suppressing X-linked inhibitor of apoptosis protein (XIAP) and survivin levels, inhibiting the growth of P-glycoproteins, and activating caspase-3/7 and caspase-9.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 385 2 Weeks
50mg USD 1315 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

UC-112, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562355
Name: UC-112
CAS#: 383392-66-3
Chemical Formula: C22H24N2O2
Exact Mass: 348.1838
Molecular Weight: 348.44
Elemental Analysis: C, 75.83; H, 6.94; N, 8.04; O, 9.18


Synonym: UC-112; UC 112; UC112;

IUPAC/Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol

InChi Key: LTGLGIQQZXSLLF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24N2O2/c25-22-18(14-24-11-4-5-12-24)13-19(20-9-6-10-23-21(20)22)16-26-15-17-7-2-1-3-8-17/h1-3,6-10,13,25H,4-5,11-12,14-16H2

SMILES Code: OC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. Eur J Med Chem. 2018 Apr 10;149:211-224. doi: 10.1016/j.ejmech.2018.02.045. Epub 2018 Feb 19. PubMed PMID: 29501942; PubMed Central PMCID: PMC5849576.

2: Xiao M, Wang J, Lin Z, Lu Y, Li Z, White SW, Miller DD, Li W. Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties. PLoS One. 2015 Jun 12;10(6):e0129807. doi: 10.1371/journal.pone.0129807. eCollection 2015. PubMed PMID: 26070194; PubMed Central PMCID: PMC4466525.

3: Wang J, Li W. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349(2):319-29. doi: 10.1124/jpet.113.212019. Epub 2014 Mar 12. PubMed PMID: 24623800; PubMed Central PMCID: PMC3989805.

4: Huang SK, Chiu AW, Pu YS, Huang YK, Chung CJ, Tsai HJ, Yang MH, Chen CJ, Hsueh YM. Arsenic methylation capability, myeloperoxidase and sulfotransferase genetic polymorphisms, and the stage and grade of urothelial carcinoma. Urol Int. 2009;82(2):227-34. doi: 10.1159/000200805. Epub 2009 Mar 19. PubMed PMID: 19322015.