WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562353
CAS#: 363600-92-4
Description: TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.
MedKoo Cat#: 562353
Name: TLR2-IN-C29
CAS#: 363600-92-4
Chemical Formula: C16H15NO4
Exact Mass: 285.1001
Molecular Weight: 285.29
Elemental Analysis: C, 67.36; H, 5.30; N, 4.91; O, 22.43
Synonym: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29;
IUPAC/Chemical Name: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid
InChi Key: WTGMGRFVBFDHGQ-RQZCQDPDSA-N
InChi Code: InChI=1S/C16H15NO4/c1-10-12(16(19)20)6-4-7-13(10)17-9-11-5-3-8-14(21-2)15(11)18/h3-9,18H,1-2H3,(H,19,20)/b17-9+
SMILES Code: O=C(O)C1=CC=CC(/N=C/C2=CC=CC(OC)=C2O)=C1C
1: Mistry P, Laird MH, Schwarz RS, Greene S, Dyson T, Snyder GA, Xiao TS, Chauhan J, Fletcher S, Toshchakov VY, MacKerell AD Jr, Vogel SN. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. doi: 10.1073/pnas.1422576112. Epub 2015 Apr 13. PubMed PMID: 25870276; PubMed Central PMCID: PMC4418912.