GDC-0927 free base
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MedKoo CAT#: 206952

CAS#: 1642297-01-5 (free base)

Description: GDC-0927, also known as SRN-927, is a next-generation oral SERD which appears to have greater potential than GDC-0810 to be a best-in-class SERD molecule. GDC-0927 targets estrogen receptor alpha (ERα), a receptor expressed in more than 70% of breast cancers, making it a popular target for the disease. GDC-0927 appears well-tolerated to date with PK exposure supporting QD dosing, evidence of robust PD target engagement, and encouragement of anti-tumor activity in heavily pretreated patients with advanced or metastatic ER+ BC, including patients with ESR1 mutations.


Chemical Structure

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GDC-0927 free base
CAS# 1642297-01-5 (free base)

Theoretical Analysis

MedKoo Cat#: 206952
Name: GDC-0927 free base
CAS#: 1642297-01-5 (free base)
Chemical Formula: C28H28FNO4
Exact Mass: 461.20
Molecular Weight: 461.530
Elemental Analysis: C, 72.87; H, 6.12; F, 4.12; N, 3.03; O, 13.87

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Related CAS #: 1642297-01-5 (free base)   1642297-02-6 (HCl)   1642297-03-7 (HBr)    

Synonym: GDC-0927; GDC 0927; GDC0927; SRN-927; SRN 927; SRN927.

IUPAC/Chemical Name: (2S)-2-(4-{2-[3-(Fluoromethyl)-1-azetidinyl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol

InChi Key: KJAAPZIFCQQQKX-NDEPHWFRSA-N

InChi Code: InChI=1S/C28H28FNO4/c1-18-25-14-23(32)7-10-26(25)34-28(27(18)21-3-2-4-22(31)13-21)20-5-8-24(9-6-20)33-12-11-30-16-19(15-29)17-30/h2-10,13-14,19,28,31-32H,11-12,15-17H2,1H3/t28-/m0/s1

SMILES Code: OC1=CC(C(C)=C(C2=CC=CC(O)=C2)[C@H](C3=CC=C(OCCN4CC(CF)C4)C=C3)O5)=C5C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: R-isomer CAS# 1642297-53-7 (free base), 1642297-54-8 (HCl), 1642297-55-9 (HBr), 1642297-56-0 (sulfate), 1642297-57-1 (phosphate), 1642297-59-3 (acetate),

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 461.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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