Ned-19
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MedKoo CAT#: 562330

CAS#: 1354235-96-3

Description: Ned-19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 310 2 Weeks
10mg USD 510 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-28. Prices are subject to change without notice.

Ned-19, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562330
Name: Ned-19
CAS#: 1354235-96-3
Chemical Formula: C30H31FN4O3
Exact Mass: 514.238
Molecular Weight: 514.6
Elemental Analysis: C, 70.02; H, 6.07; F, 3.69; N, 10.89; O, 9.33


Synonym: Ned-19; Ned 19; Ned19;

IUPAC/Chemical Name: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

InChi Key: FUHCEERDBRGPQZ-LBNVMWSVSA-N

InChi Code: InChI=1S/C30H31FN4O3/c1-38-27-11-10-19(16-20(27)18-34-12-14-35(15-13-34)26-9-5-3-7-23(26)31)28-29-22(17-25(33-28)30(36)37)21-6-2-4-8-24(21)32-29/h2-11,16,25,28,32-33H,12-15,17-18H2,1H3,(H,36,37)/t25-,28+/m0/s1

SMILES Code: O=C([C@@H]1CC2=C([C@@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Jiang Y, Zhou Y, Peng G, Tian H, Pan D, Liu L, Yang X, Li C, Li W, Chen L, Ran P, Dai A. Two-pore channels mediated receptor-operated Ca(2+) entry in pulmonary artery smooth muscle cells in response to hypoxia. Int J Biochem Cell Biol. 2018 Jan 31;97:28-35. doi: 10.1016/j.biocel.2018.01.012. [Epub ahead of print] PubMed PMID: 29355755.

2: Padamsey Z, McGuinness L, Emptage NJ. Inhibition of lysosomal Ca(2+) signalling disrupts dendritic spine structure and impairs wound healing in neurons. Commun Integr Biol. 2017 Nov 3;10(5-6):e1344802. doi: 10.1080/19420889.2017.1344802. eCollection 2017. PubMed PMID: 29259727; PubMed Central PMCID: PMC5731510.

3: Suárez-Cortés P, Gambara G, Favia A, Palombi F, Alano P, Filippini A. Ned-19 inhibition of parasite growth and multiplication suggests a role for NAADP mediated signalling in the asexual development of Plasmodium falciparum. Malar J. 2017 Sep 12;16(1):366. doi: 10.1186/s12936-017-2013-7. PubMed PMID: 28899381; PubMed Central PMCID: PMC5596470.

4: Avdonin PV, Nadeev AD, Tsitrin EB, Tsitrina AA, Avdonin PP, Mironova GY, Zharkikh IL, Goncharov NV. Involvement of two-pore channels in hydrogen peroxide-induced increase in the level of calcium ions in the cytoplasm of human umbilical vein endothelial cells. Dokl Biochem Biophys. 2017 May;474(1):209-212. doi: 10.1134/S1607672917030152. Epub 2017 Jul 20. PubMed PMID: 28726088.

5: Kelu JJ, Webb SE, Parrington J, Galione A, Miller AL. Ca(2+) release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos. Dev Biol. 2017 May 15;425(2):109-129. doi: 10.1016/j.ydbio.2017.03.031. Epub 2017 Apr 6. PubMed PMID: 28390800.

6: Rah SY, Lee YH, Kim UH. NAADP-mediated Ca(2+) signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31(7):3126-3137. doi: 10.1096/fj.201601290R. Epub 2017 Apr 6. PubMed PMID: 28386045; PubMed Central PMCID: PMC5471520.

7: Di Nezza F, Zuccolo E, Poletto V, Rosti V, De Luca A, Moccia F, Guerra G, Ambrosone L. Liposomes as a Putative Tool to Investigate NAADP Signaling in Vasculogenesis. J Cell Biochem. 2017 Nov;118(11):3722-3729. doi: 10.1002/jcb.26019. Epub 2017 May 16. PubMed PMID: 28374913.

8: Nguyen ON, Grimm C, Schneider LS, Chao YK, Atzberger C, Bartel K, Watermann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM. Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells. Cancer Res. 2017 Mar 15;77(6):1427-1438. doi: 10.1158/0008-5472.CAN-16-0852. Epub 2017 Jan 20. PubMed PMID: 28108508.

9: Pereira GJ, Antonioli M, Hirata H, Ureshino RP, Nascimento AR, Bincoletto C, Vescovo T, Piacentini M, Fimia GM, Smaili SS. Glutamate induces autophagy via the two-pore channels in neural cells. Oncotarget. 2017 Feb 21;8(8):12730-12740. doi: 10.18632/oncotarget.14404. PubMed PMID: 28055974; PubMed Central PMCID: PMC5355049.

10: Kunawudhi A, Sereeborwornthanasak K, Promteangtrong C, Siripongpreeda B, Vanprom S, Chotipanich C. Value of FDG PET/Contrast-Enhanced CT in Initial Staging of Colorectal Cancer - Comparison with Contrast-Enhanced CT. Asian Pac J Cancer Prev. 2016;17(8):4071-5. PubMed PMID: 27644663.

11: Khalaf A, Babiker F. Discrepancy in calcium release from the sarcoplasmic reticulum and intracellular acidic stores for the protection of the heart against ischemia/reperfusion injury. J Physiol Biochem. 2016 Sep;72(3):495-508. doi: 10.1007/s13105-016-0498-0. Epub 2016 Jun 21. PubMed PMID: 27325083.

12: Kintzer AF, Stroud RM. Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana. Nature. 2016 Mar 10;531(7593):258-62. doi: 10.1038/nature17194. PubMed PMID: 26961658; PubMed Central PMCID: PMC4863712.

13: Lee CS, Tong BC, Cheng CW, Hung HC, Cheung KH. Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology. Sci Rep. 2016 Feb 3;6:20282. doi: 10.1038/srep20282. PubMed PMID: 26838264; PubMed Central PMCID: PMC4738322.

14: Favia A, Pafumi I, Desideri M, Padula F, Montesano C, Passeri D, Nicoletti C, Orlandi A, Del Bufalo D, Sergi M, Ziparo E, Palombi F, Filippini A. NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis. Sci Rep. 2016 Jan 6;6:18925. doi: 10.1038/srep18925. PubMed PMID: 26733361; PubMed Central PMCID: PMC4702115.

15: Ali RA, Camick C, Wiles K, Walseth TF, Slama JT, Bhattacharya S, Giovannucci DR, Wall KA. Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. J Biol Chem. 2016 Feb 26;291(9):4503-22. doi: 10.1074/jbc.M115.681833. Epub 2016 Jan 4. PubMed PMID: 26728458; PubMed Central PMCID: PMC4813477.

16: Kelu JJ, Chan HL, Webb SE, Cheng AH, Ruas M, Parrington J, Galione A, Miller AL. Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca(2+) signaling during myogenesis in intact zebrafish. Int J Dev Biol. 2015;59(7-9):313-25. doi: 10.1387/ijdb.150206am. PubMed PMID: 26679948.

17: Davidson SM, Foote K, Kunuthur S, Gosain R, Tan N, Tyser R, Zhao YJ, Graeff R, Ganesan A, Duchen MR, Patel S, Yellon DM. Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc Res. 2015 Dec 1;108(3):357-66. doi: 10.1093/cvr/cvv226. Epub 2015 Sep 22. PubMed PMID: 26395965; PubMed Central PMCID: PMC4648198.

18: Xu M, Li XX, Wang L, Wang M, Zhang Y, Li PL. Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. Cell Physiol Biochem. 2015;37(2):432-44. doi: 10.1159/000430366. Epub 2015 Aug 28. PubMed PMID: 26315049; PubMed Central PMCID: PMC4678283.

19: Bychkova SV, Chorna TI. NAADP-sensitive Ca2+ stores in permeabilized rat hepatocytes. Ukr Biochem J. 2014 Sep-Oct;86(5):65-73. PubMed PMID: 25816589.

20: Favia A, Desideri M, Gambara G, D'Alessio A, Ruas M, Esposito B, Del Bufalo D, Parrington J, Ziparo E, Palombi F, Galione A, Filippini A. VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4706-15. doi: 10.1073/pnas.1406029111. Epub 2014 Oct 20. PubMed PMID: 25331892; PubMed Central PMCID: PMC4226099.