Omtriptolide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341173

CAS#: 195883-06-8

Description: Omtriptolide is a biochemical.

Chemical Structure

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Omtriptolide
CAS# 195883-06-8
Instruction

Theoretical Analysis

MedKoo Cat#: 341173
Name: Omtriptolide
CAS#: 195883-06-8
Chemical Formula: C24H28O9
Exact Mass: 460.17
Molecular Weight: 460.479
Elemental Analysis: C, 62.60; H, 6.13; O, 31.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Omtriptolide; YM 262; YM-262; YM262.

IUPAC/Chemical Name: UNII-D36ELM729P

InChi Key: HROMYAWHLUOUPY-AHCCQAQQSA-N

InChi Code: InChI=1S/C24H28O9/c1-10(2)22-17(32-22)18-24(33-18)21(3)7-6-11-12(9-29-19(11)28)13(21)8-14-23(24,31-14)20(22)30-16(27)5-4-15(25)26/h10,13-14,17-18,20H,4-9H2,1-3H3,(H,25,26)/t13-,14-,17-,18-,20+,21-,22-,23+,24+/m0/s1

SMILES Code: CC(C)[C@]12O[C@H]1[C@@H]3O[C@@]34[C@@]5(C)CCC6=C(COC6=O)[C@@H]5C[C@@H]7O[C@]47[C@@H]2OC(=O)CCC(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 460.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kim HJ, Ravichandran K, Ozkok A, Wang Q, He Z, Jani A, Ljubanovic D, Douglas IS, Edelstein CL. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349(3):518-25. doi: 10.1124/jpet.114.213769. Epub 2014 Apr 11. PubMed PMID: 24727856.

2: Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS. Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs. Am J Respir Crit Care Med. 2012 Jul 1;186(1):72-81. doi: 10.1164/rccm.201109-1593OC. Epub 2012 May 10. PubMed PMID: 22582160; PubMed Central PMCID: PMC3400991.

3: Danel C, Duval C, Azaroual N, Vaccher C, Bonte JP, Bailly C, Landy D, Goossens JF. Complexation of triptolide and its succinate derivative with cyclodextrins: affinity capillary electrophoresis, isothermal titration calorimetry and 1H NMR studies. J Chromatogr A. 2011 Dec 2;1218(48):8708-14. doi: 10.1016/j.chroma.2011.10.007. Epub 2011 Oct 8. PubMed PMID: 22033106.

4: Chen G, Sun H, Arp J, Garcia B, Wang X, Wise Y, Liu W, Ramcharran S, Huang X, Xiang Y, Yang H, Fang Z, Madrenas J, Sudo Y, Tamura K, Zhong R. A synergistic effect between PG490-88 and tacrolimus prolongs renal allograft survival in monkeys. Am J Transplant. 2006 Apr;6(4):714-23. Erratum in: Am J Transplant. 2006 Jun;6(6):1498. Madenas, J [corrected to Madrenas, J]. PubMed PMID: 16539628.

5: Wang X, Sun H, Chen G, Liu W, Wise Y, Yung C, Sudo Y, Tamura K, Garcia B, Zhong R. Immunosuppression with a combination of pg490-88 and a subtherapeutic dose of FK506 in a canine renal allograft model. Transplantation. 2005 Jun 15;79(11):1537-44. PubMed PMID: 15940043.

6: Fisniku O, Pan F, Wynn C, Erickson LM, Crews G, Jang MS, Sudo Y, Tamura K, Kobayashi M, Benediktsson H, Jiang H. Protective effects of PG490-88 on chronic allograft rejection by changing intragraft gene expression profiles. Transplant Proc. 2005 May;37(4):1962-4. PubMed PMID: 15919518.

7: Pan F, Fisniku O, Wynn C, Erickson LM, Crews G, Jang MS, Sudo Y, Tamura K, Kobayashi M, Benediktsson H, Jiang H. PG490-88, a new immunosuppressant, effectively prevents acute and chronic rejection in rat renal allografts. Transplant Proc. 2005 Jan-Feb;37(1):134-6. PubMed PMID: 15808572.

8: Fidler JM, Li K, Chung C, Wei K, Ross JA, Gao M, Rosen GD. PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. Mol Cancer Ther. 2003 Sep;2(9):855-62. PubMed PMID: 14555704.

9: Leonard CT, Soccal PM, Berry GJ, Doyle RL, Theodore J, Duncan SR, Rosen GD. PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant. 2002 Dec;21(12):1314-8. PubMed PMID: 12490278.

10: Chen BJ, Chen Y, Cui X, Fidler JM, Chao NJ. Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. Transplantation. 2002 Jan 15;73(1):115-21. PubMed PMID: 11792990.

11: Chen BJ, Liu C, Cui X, Fidler JM, Chao NJ. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000 Nov 27;70(10):1442-7. PubMed PMID: 11118087.