WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527796

CAS#: 79094-20-5

Description: Daltroban is a selective thromboxane A2 receptor antagonist.

Chemical Structure

CAS# 79094-20-5

Theoretical Analysis

MedKoo Cat#: 527796
Name: Daltroban
CAS#: 79094-20-5
Chemical Formula: C16H16ClNO4S
Exact Mass: 353.0489
Molecular Weight: 353.817
Elemental Analysis: C, 54.32; H, 4.56; Cl, 10.02; N, 3.96; O, 18.09; S, 9.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Daltroban

IUPAC/Chemical Name: 4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid


InChi Code: InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)

SMILES Code: O=C(O)CC1=CC=C(CCNS(=O)(C2=CC=C(Cl)C=C2)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 353.817 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Brantl SA, Khandoga AL, Siess W. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. Platelets. 2014;25(3):151-61. doi: 10.3109/09537104.2013.803530. Epub 2013 Jun 21. PubMed PMID: 23789792.

2: Kylhammar D, Rådegran G. Cyclooxygenase-2 inhibition and thromboxane A(2) receptor antagonism attenuate hypoxic pulmonary vasoconstriction in a porcine model. Acta Physiol (Oxf). 2012 Aug;205(4):507-19. doi: 10.1111/j.1748-1716.2012.02437.x. Epub 2012 May 4. PubMed PMID: 22554045.

3: Leal AK, McCord JL, Tsuchimochi H, Kaufman MP. Blockade of the TP receptor attenuates the exercise pressor reflex in decerebrated rats with chronic femoral artery occlusion. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2140-6. doi: 10.1152/ajpheart.00403.2011. Epub 2011 Aug 19. PubMed PMID: 21856914; PubMed Central PMCID: PMC3213975.

4: Malinowska B, Zakrzeska A, Kurz CM, Göthert M, Kwolek G, Wielgat P, Braszko JJ, Schlicker E. Involvement of central beta2-adrenergic, NMDA and thromboxane A2 receptors in the pressor effect of anandamide in rats. Naunyn Schmiedebergs Arch Pharmacol. 2010 Apr;381(4):349-60. doi: 10.1007/s00210-010-0497-6. Epub 2010 Mar 3. PubMed PMID: 20198363.

5: Okamoto Y, Yokota M, Kawazoe S, Kubota H, Nagaoka H, Arakida Y, Takeuchi M. A novel dual antagonist of thromboxane A2 and leukotriene D4 receptors: synthesis and structure-activity relationships of chloroquinolylvinyl derivatives. Chem Pharm Bull (Tokyo). 2006 May;54(5):603-10. PubMed PMID: 16651753.

6: Grandel U, Hopf M, Buerke M, Hattar K, Heep M, Fink L, Bohle RM, Morath S, Hartung T, Pullamsetti S, Schermuly RT, Seeger W, Grimminger F, Sibelius U. Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts. Circulation. 2005 Aug 2;112(5):691-8. Epub 2005 Jul 25. PubMed PMID: 16043646.

7: Desjardins F, Aubin MC, Carrier M, Perrault LP. Decrease of endothelin receptor subtype ETB and release of COX-derived products contribute to endothelial dysfunction of porcine epicardial coronary arteries in left ventricular hypertrophy. J Cardiovasc Pharmacol. 2005 Jun;45(6):499-508. PubMed PMID: 15897775.

8: Pestel S, Schlaf G, Götze O, Jungermann K, Schieferdecker HL. Differences in the involvement of prostanoids from Kupffer cells in the mediation of anaphylatoxin C5a-, zymosan-, and lipopolysaccharide-dependent hepatic glucose output and flow reduction. Lab Invest. 2003 Dec;83(12):1733-41. PubMed PMID: 14691291.

9: Pestel S, Nath A, Jungermann K, Schieferdecker HL. Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. Biochem Pharmacol. 2003 Aug 15;66(4):643-52. PubMed PMID: 12906929.

10: Baber SR, Champion HC, Bivalacqua TJ, Hyman AL, Kadowitz PJ. Role of cyclooxygenase-2 in the generation of vasoactive prostanoids in the rat pulmonary and systemic vascular beds. Circulation. 2003 Aug 19;108(7):896-901. Epub 2003 Aug 4. PubMed PMID: 12900348.

11: Ge ZD, Auchampach JA, Piper GM, Gross GJ. Comparison of cardioprotective efficacy of two thromboxane A2 receptor antagonists. J Cardiovasc Pharmacol. 2003 Mar;41(3):481-8. PubMed PMID: 12605028.

12: Marusawa H, Setoi H, Sawada A, Kuroda A, Seki J, Motoyama Y, Tanaka H. Synthesis and biological activity of 1-phenylsulfonyl-4-phenylsulfonylaminopyrrolidine derivatives as thromboxane a(2) receptor antagonists. Bioorg Med Chem. 2002 May;10(5):1399-415. PubMed PMID: 11886803.

13: Koleva M, Schlaf G, Landmann R, Götze O, Jungermann K, Schieferdecker HL. Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: mediation by interleukin-6 from Kupffer cells. Gastroenterology. 2002 Mar;122(3):697-708. PubMed PMID: 11875003.

14: Vezza R, Mezzasoma AM, Venditti G, Gresele P. Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets. Thromb Haemost. 2002 Jan;87(1):114-21. PubMed PMID: 11848439.

15: Podjarny E, Benchetrit S, Katz B, Green J, Bernheim J. Effect of methyldopa on renal function in rats with L-NAME-induced hypertension in pregnancy. Nephron. 2001 Aug;88(4):354-9. PubMed PMID: 11474231.

16: Grandel U, Fink L, Blum A, Heep M, Buerke M, Kraemer HJ, Mayer K, Bohle RM, Seeger W, Grimminger F, Sibelius U. Endotoxin-induced myocardial tumor necrosis factor-alpha synthesis depresses contractility of isolated rat hearts: evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production. Circulation. 2000 Nov 28;102(22):2758-64. PubMed PMID: 11094044.

17: Schieferdecker HL, Schlaf G, Koleva M, Götze O, Jungermann K. Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6. J Immunol. 2000 May 15;164(10):5453-8. PubMed PMID: 10799912.

18: Tanaka T, Fukuta Y, Fukuda Y, Higashino R, Ito S, Takei M, Tamaki H, Kurimoto T, Suzuki Y. Z-335, a thromboxane A2 receptor antagonist, suppresses the progression of arachidonic acid-induced hind limb gangrene in rats. Biol Pharm Bull. 1999 Dec;22(12):1382-4. PubMed PMID: 10746175.

19: Sibelius U, Grandel U, Buerke M, Mueller D, Kiss L, Kraemer HJ, Braun-Dullaeus R, Haberbosch W, Seeger W, Grimminger F. Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. Circulation. 2000 Jan 4-11;101(1):78-85. PubMed PMID: 10618308.

20: Arakida Y, Ohga K, Suwa K, Yokota M, Miyata K, Yamada T, Honda K. Effects of lipid mediator antagonists on predominant mediator-controlled asthmatic reactions in passively sensitized guinea pigs. J Pharmacol Exp Ther. 1999 Sep;290(3):1285-91. PubMed PMID: 10454505.