E 4441

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584380

CAS#: 124668-12-8

Description: E 4441 is a third-generation difluoroquinolone and shows satisfactory levels of activity, both in vitro and in vivo, its activity against G(+) aerobic bacteria and anaerobic bacteria.

Chemical Structure

E 4441
CAS# 124668-12-8

Theoretical Analysis

MedKoo Cat#: 584380
Name: E 4441
CAS#: 124668-12-8
Chemical Formula: C17H17F2N3O3
Exact Mass: 349.1238
Molecular Weight: 349.3378
Elemental Analysis: C, 58.45; H, 4.91; F, 10.88; N, 12.03; O, 13.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: E 4441; E-4441; E4441

IUPAC/Chemical Name: 3-Quinolinecarboxylic acid, 7-(3-amino-3-methyl-1-azetidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-


InChi Code: InChI=1S/C17H17F2N3O3/c1-17(20)6-21(7-17)14-11(18)4-9-13(12(14)19)22(8-2-3-8)5-10(15(9)23)16(24)25/h4-5,8H,2-3,6-7,20H2,1H3,(H,24,25)

SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CC(C)(N)C4)=C3F)C1=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 349.3378 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Martinez L, Basi N, Dordal A, Roser R, Sagarra R. A pharmacokinetic study of E-4441, a new quinolone, in the rat, mouse and cynomolgus monkey. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:352-6. PubMed PMID: 1668199.

2: Esteve M, Moros M, Coll R, Xicota MA, Llovera S. Antimicrobial activity of E-4441, a representative azetidine quinolone. Drugs Exp Clin Res. 1990;16(9):445-9. PubMed PMID: 2100245.

3: Gargallo-Viola D, Esteve M, Moros M, Coll R, Xicota MA, de Andres C, Roser R, Guinea J. Comparative in vitro and in vivo activities of six new monofluoroquinolone and difluoroquinolone 3-carboxylic acids with a 7-azetidin ring substituent. Antimicrob Agents Chemother. 1990 Dec;34(12):2318-26. PubMed PMID: 2088187; PubMed Central PMCID: PMC172054.