Naloxonazine Dihydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562325

CAS#: 880759-65-9

Description: Naloxonazine Dihydrochloride is a potent and selective antagonist for μ1 opioid receptors.


Price and Availability

Size
Price

10mg
USD 250
Size
Price

50mg
USD 600
Size
Price

250mg
USD 1450

Naloxonazine Dihydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562325
Name: Naloxonazine Dihydrochloride
CAS#: 880759-65-9
Chemical Formula: C38H44Cl2N4O6
Exact Mass:
Molecular Weight: 723.69
Elemental Analysis: C, 63.07; H, 6.13; Cl, 9.80; N, 7.74; O, 13.26


Synonym: Naloxonazine Dihydrochloride; Naloxonazine 2HCl;

IUPAC/Chemical Name: (4aS,7aS,Z)-3-allyl-7-(((4aS,7aS,12bS,Z)-3-allyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-ylidene)hydrazono)-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol dihydrochloride

InChi Key: VIAIHLLKDJKEKM-PATAXOJOSA-N

InChi Code: InChI=1S/C38H42N4O6.2ClH/c1-3-15-41-17-13-35-29-21-5-7-25(43)31(29)47-33(35)23(9-11-37(35,45)27(41)19-21)39-40-24-10-12-38(46)28-20-22-6-8-26(44)32-30(22)36(38,34(24)48-32)14-18-42(28)16-4-2;;/h3-8,27-28,33-34,43-46H,1-2,9-20H2;2*1H/b39-23-,40-24-;;/t27?,28?,33-,34-,35+,36?,37-,38-;;/m1../s1

SMILES Code: C=CCN1CCC2([C@H](O3)/C(CC4)=N\N=C5CC[C@](C(C6)N(CC=C)CC7)(O)[C@]87[C@@H]\5OC9=C(O)C=CC6=C98)[C@]4(O)C1CC%10=C2C3=C(O)C=C%10.Cl.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Xia M, Guo V, Huang R, Shahane SA, Austin CP, Nirenberg M, Sharma SK. Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. Cell Mol Neurobiol. 2011 Aug;31(6):901-7. doi: 10.1007/s10571-011-9689-y. Epub 2011 May 20. PubMed PMID: 21598037; PubMed Central PMCID: PMC3146558.

2: Joly N, Vaillant C, Cohen AM, Martin P, El Essassi M, Massoui M, Banoub J. Structural determination of the novel fragmentation routes of zwitteronic morphine opiate antagonists naloxonazine and naloxone hydrochlorides using electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(6):1062-74. PubMed PMID: 17310471.