DA-E 5090

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581145

CAS#: 131420-84-3

Description: DA-E 5090 is deacetylated form of E5090, is pharmacologically active metabolite of E 5090, is interleukin-1 antagonist. DA-E 5090 is a novel inhibitor of IL-1 generation, in vitro inhibitory effects on the generation of IL-1 by human monocytes. E5090 is an orally active inhibitor of IL-1 generation, being converted in vivo into the pharmacologically active deacetylated form (DA-E5090). In vitro effects of DA-E5090 on the generation of IL-1 by human monocytes stimulated with LPS were examined. DA-E5090 inhibited both IL-1 alpha and IL-1 beta generation by human monocytes stimulated with 1 microgram/ml of LPS in a dose dependent-manner (1-10 microM), as determined by LAF assay and ELISA. Northern blotting analysis indicated that DA-E5090 inhibits transcription of IL-1 alpha and IL-1 beta m-RNAs.


Chemical Structure

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DA-E 5090
CAS# 131420-84-3

Theoretical Analysis

MedKoo Cat#: 581145
Name: DA-E 5090
CAS#: 131420-84-3
Chemical Formula: C17H18O4
Exact Mass: 286.1205
Molecular Weight: 286.33
Elemental Analysis: C, 71.31; H, 6.34; O, 22.35

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: DA-E 5090; DA-E5090; DA E 5090; DA-E-5090; DA-E-5090;

IUPAC/Chemical Name: (Z)-3-(5-Ethyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acid

InChi Key: WGNQQQSMLCOUAX-NTMALXAHSA-N

InChi Code: InChI=1S/C17H18O4/c1-4-11-6-5-7-13-12(8-10(2)17(19)20)9-14(21-3)16(18)15(11)13/h5-9,18H,4H2,1-3H3,(H,19,20)/b10-8-

SMILES Code: O=C(O)/C(C)=C\C1=C2C=CC=C(CC)C2=C(O)C(OC)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 286.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Tanaka M, Chiba K, Okita M, Kaneko T, Tagami K, Hibi S, Okamoto Y, Shirota H, Goto M, Sakurai H, et al. 3-(5-Alkyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acids as orally active inhibitors of IL-1 generation. J Med Chem. 1991 Aug;34(8):2647-9. PubMed PMID: 1875355.

2: Goto M, Chiba K, Hashida R, Shirota H. A novel inhibitor of IL-1 generation, E5090: in vitro inhibitory effects on the generation of IL-1 by human monocytes. Agents Actions Suppl. 1991;32:225-9. PubMed PMID: 2069091.