YM 16638

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341165

CAS#: 104073-72-5

Description: YM 16638 is a biochemical.


Chemical Structure

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YM 16638
CAS# 104073-72-5

Theoretical Analysis

MedKoo Cat#: 341165
Name: YM 16638
CAS#: 104073-72-5
Chemical Formula: C18H22N2O5S3
Exact Mass: 442.0691
Molecular Weight: 442.563
Elemental Analysis: C, 48.85; H, 5.01; N, 6.33; O, 18.08; S, 21.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: YM 16638; YM-16638; YM16638.

IUPAC/Chemical Name: Acetic acid, ((5-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)-1,3,4-thiadiazol-2-yl)thio)-

InChi Key: RRUNJEUMTFLLDY-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H22N2O5S3/c1-3-5-13-14(7-6-12(11(2)21)16(13)24)25-8-4-9-26-17-19-20-18(28-17)27-10-15(22)23/h6-7,24H,3-5,8-10H2,1-2H3,(H,22,23)

SMILES Code: C(CSc1sc(nn1)SCCCOc1c(c(c(cc1)C(=O)C)O)CCC)(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 442.563 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Tohda Y. [My research on asthma today and in the future]. Arerugi. 2013 Nov;62(11):1501-14. Review. Japanese. PubMed PMID: 24552761.

2: Goto S, Shimokawa T. Effect of the hypocholesterolemic agent YM-16638 on cholesterol biosynthesis activity and apolipoprotein B secretion in HepG2 and monkey liver. Jpn J Pharmacol. 1999 Jan;79(1):75-82. PubMed PMID: 10082320.

3: Goto S, Shimokawa T, Ugawa T, Hisamichi N, Masuyama Y, Iizumi Y, Sato N, Takenaka T, Kodama T. Species specificity in the blood cholesterol-lowering effect of YM-16638. Br J Pharmacol. 1996 May;118(1):174-8. PubMed PMID: 8733592; PubMed Central PMCID: PMC1909480.

4: Miyata K, Kamato T, Nishida A, Takizawa K, Takeda M. Gastric mucosal protection by YM638, a novel leukotriene D4 receptor antagonist, in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):165-75. PubMed PMID: 7781686.

5: Kobayashi K, Fukuda T, Higuchi K, Nakamura H, Arakawa T. Role of leukotrienes in indomethacin-induced mucosal damage in rats. J Clin Gastroenterol. 1993;17 Suppl 1:S11-4. PubMed PMID: 8283004.

6: Yoshikawa T, Ichikawa H, Naito Y, Kondo M. Role of leukotrienes in gastric mucosal injury induced by ischemia-reperfusion in rats. J Clin Gastroenterol. 1992;14 Suppl 1:S68-70. PubMed PMID: 1629580.

7: Filep JG, Battistini B, Sirois P. Pharmacological modulation of endothelin-induced contraction of guinea-pig isolated airways and thromboxane release. Br J Pharmacol. 1991 Jul;103(3):1633-40. PubMed PMID: 1933129; PubMed Central PMCID: PMC1907823.

8: Tomioka K, Jackowski JT, Abraham WM. Characterization of sulfidopeptide leukotriene responses in sheep tracheal smooth muscle in vitro. Can J Physiol Pharmacol. 1991 Jun;69(6):805-11. PubMed PMID: 1655181.

9: Osada T, Goto H, Tsukamoto Y, Nakazawa S, Sugiyama S, Ozawa T. Role of leukotrienes in hydrochloric acid-induced gastric lesions in rats. Dig Dis Sci. 1990 Feb;35(2):186-92. PubMed PMID: 2105876.

10: Tomioka K, Garrido R, Stevenson JS, Abraham WM. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):43-7. PubMed PMID: 2740413.

11: Tomioka K, Yamada T, Mase T, Hara H, Murase K. Pharmacological properties of the orally active leukotriene antagonist [[5-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl]thio]-1,3,4- thiadiazol-2-yl]thio]acetic acid. Arzneimittelforschung. 1988 May;38(5):682-5. PubMed PMID: 3415708.