WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581136
Description: DA 4643 is one of histamine H2-receptor antagonistic. Two histamine H2-receptor antagonists of the phenylformamidine type, mifentidine (N-isopropyl-N'-(4-1H-imidazol-4-yl-phenyl) formamidine dihydrochloride; I) and DA 4643 (N-methyl-N'-(3-(2-guanidinothiazol-4-yl)-phenyl) formamidine dihydrochloride; II), have been investigated by experimental physico-chemical studies and theoretical conformational analysis. Both mifentidine and DA 4643 interact with the histamine H2-receptor at the same site, utilizing in the binding process the same, or closely similar, receptor structural features.
MedKoo Cat#: 581136
Name: DA 4643
Chemical Formula: C12H14N6S
Exact Mass: 274.1001
Molecular Weight: 274.35
Elemental Analysis: C, 52.54; H, 5.14; N, 30.63; S, 11.69
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Synonym: DA 4643; DA-4643; DA4643;
IUPAC/Chemical Name: N-Methyl-N'-(3-(2-guanidinothiazol-4-yl)phenyl)formamidine
InChi Key: MRTUBNJTWHQTJJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H14N6S/c1-15-7-16-9-4-2-3-8(5-9)10-6-19-12(17-10)18-11(13)14/h2-7H,1H3,(H,15,16)(H4,13,14,17,18)
SMILES Code: N=C(N)NC1=NC(C2=CC(/N=C/NC)=CC=C2)=CS1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 274.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Donetti A, Trummlitz G, Bietti G, Cereda E, Bazzano C, Wagner HU. Conformational studies of two histamine H2-receptor antagonistic phenylformamidines: mifentidine and its guanidinothiazole analogue DA 4643. Arzneimittelforschung. 1985;35(1A):306-15. PubMed PMID: 2859031.
2: Paquay JB, Bolscher MT, Voss HP, Timmerman H, Bast A. Difference in the inhibition of nitric oxide synthase and cytochrome P-450 by some H(2)-antagonists. Toxicol In Vitro. 1997 Dec;11(6):775-8. PubMed PMID: 20654383.