2-Methylserotonin maleate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527772

CAS#: 78263-91-9

Description: 2-Methylserotonin maleate is a selective full agonist at the 5-HT3 receptor.


Chemical Structure

img
2-Methylserotonin maleate
CAS# 78263-91-9

Theoretical Analysis

MedKoo Cat#: 527772
Name: 2-Methylserotonin maleate
CAS#: 78263-91-9
Chemical Formula: C15H18N2O5
Exact Mass: 306.1216
Molecular Weight: 306.318
Elemental Analysis: C, 58.82; H, 5.92; N, 9.15; O, 26.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 2-Methylserotonin maleate

IUPAC/Chemical Name: 3-(2-Aminoethyl)-2-methyl-1H-indol-5-ol Maleate

InChi Key: KFEAUMZKRNJEDU-BTJKTKAUSA-N

InChi Code: InChI=1S/C11H14N2O.C4H4O4/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7;5-3(6)1-2-4(7)8/h2-3,6,13-14H,4-5,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: OC1=CC2=C(NC(C)=C2CCN)C=C1.O=C(O)/C=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 306.318 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ishizuka O, Gu B, Igawa Y, Nishizawa O, Pehrson R, Andersson KE. Role of supraspinal serotonin receptors for micturition in normal conscious rats. Neurourol Urodyn. 2002;21(3):225-30. PubMed PMID: 11948716.

2: Paul D, Yao D, Zhu P, Minor LD, Garcia MM. 5-hydroxytryptamine3 (5-HT3) receptors mediate spinal 5-HT antinociception: an antisense approach. J Pharmacol Exp Ther. 2001 Aug;298(2):674-8. PubMed PMID: 11454930.

3: Martin SM, Wilson BC, Chen X, Takahashi Y, Poulin P, Pittman QJ. Vagal CCK and 5-HT(3) receptors are unlikely to mediate LPS or IL-1beta-induced fever. Am J Physiol Regul Integr Comp Physiol. 2000 Sep;279(3):R960-5. PubMed PMID: 10956254.

4: Ormazábal MJ, Goicoechea C, Alfaro MJ, Sánchez E, Martín MI. Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors. Brain Res. 1999 Oct 23;845(2):130-8. PubMed PMID: 10536192.

5: Carter D, Champney M, Hwang B, Eglen RM. Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum. Eur J Pharmacol. 1995 Jul 14;280(3):243-50. PubMed PMID: 8566092.

6: Xu W, Qiu XC, Han JS. Serotonin receptor subtypes in spinal antinociception in the rat. J Pharmacol Exp Ther. 1994 Jun;269(3):1182-9. PubMed PMID: 8014862.

7: Benloucif S, Keegan MJ, Galloway MP. Serotonin-facilitated dopamine release in vivo: pharmacological characterization. J Pharmacol Exp Ther. 1993 Apr;265(1):373-7. PubMed PMID: 8474019.

8: Cohen ML, Bloomquist W, Gidda JS, Lacefield W. LY277359 maleate: a potent and selective 5-HT3 receptor antagonist without gastroprokinetic activity. J Pharmacol Exp Ther. 1990 Jul;254(1):350-5. PubMed PMID: 2366187.