WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555187

CAS#: 144707-18-6

Description: 2-D08 is a synthetic flavone that inhibits sumoylation. 2-D08 showed anti-aggregatory and neuroprotective effect

Price and Availability

Size Price Shipping out time Quantity
100mg USD 1150 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2750 2 Weeks
1g USD 3950 2 Weeks
2g USD 5950 2 Weeks
5g USD 9850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-27. Prices are subject to change without notice.

2-D08, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555187
Name: 2-D08
CAS#: 144707-18-6
Chemical Formula: C15H10O5
Exact Mass: 270.0528
Molecular Weight: 270.24
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60

Synonym: 2-D08; 2D08; 2 D08.

IUPAC/Chemical Name: 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one


InChi Code: InChI=1S/C15H10O5/c16-10-6-5-9(14(18)15(10)19)13-7-11(17)8-3-1-2-4-12(8)20-13/h1-7,16,18-19H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Baik H, Boulanger M, Hosseini M, Kowalczyk J, Zaghdoudi S, Salem T, Sarry JE, Hicheri Y, Cartron G, Piechaczyk M, Bossis G. Targeting the SUMO pathway primes all-trans retinoic acid-induced differentiation of non-promyelocytic acute myeloid leukemias. Cancer Res. 2018 Feb 27. pii: canres.3361.2017. doi: 10.1158/0008-5472.CAN-17-3361. [Epub ahead of print] PubMed PMID: 29487199.

2: Yu F, Wang L, Wang H, Sheng J, Lu L. Repression of SUMOylation pathway by grass carp reovirus contributes to the upregulation of PKR in an IFN-independent manner. Oncotarget. 2017 Aug 17;8(42):71500-71511. doi: 10.18632/oncotarget.20309. eCollection 2017 Sep 22. PubMed PMID: 29069722; PubMed Central PMCID: PMC5641065.

3: Marsh DT, Das S, Ridell J, Smid SD. Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08). Bioorg Med Chem. 2017 Jul 15;25(14):3827-3834. doi: 10.1016/j.bmc.2017.05.041. Epub 2017 May 19. PubMed PMID: 28559058.

4: Kim YS, Keyser SG, Schneekloth JS Jr. Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7. doi: 10.1016/j.bmcl.2014.01.010. Epub 2014 Jan 11. PubMed PMID: 24468414; PubMed Central PMCID: PMC3970184.