WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562273
Description: WB-308 is a inhibitor of the epidermal growth factor receptor (EGFR). It acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis.
MedKoo Cat#: 562273
Chemical Formula: C19H17FN2O
Exact Mass: 308.1325
Molecular Weight: 308.35
Elemental Analysis: C, 74.01; H, 5.56; F, 6.16; N, 9.08; O, 5.19
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: WB-308; WB 308; WB308;
IUPAC/Chemical Name: 1-(6-Fluoro-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2-phenyl-ethanone
InChi Key: HLKIUOZYYGXOOR-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17FN2O/c20-14-6-7-17-16(11-14)15-8-9-22(12-18(15)21-17)19(23)10-13-4-2-1-3-5-13/h1-7,11,21H,8-10,12H2
SMILES Code: FC1=CC2=C(NC3=C2CCN(C(CC4=CC=CC=C4)=O)C3)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 308.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Li J, Deng H, Hu M, Fang Y, Vaughn A, Cai X, Xu L, Wan W, Li Z, Chen S, Yang X, Wu S, Xiao J. Inhibition of non-small cell lung cancer (NSCLC) growth by a novel small molecular inhibitor of EGFR. Oncotarget. 2015 Mar 30;6(9):6749-61. PubMed PMID: 25730907; PubMed Central PMCID: PMC4466647.