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MedKoo CAT#: 581125

CAS#: 5061-22-3

Description: Nafiverine is a new antispasmodic. The stability of nafiverine, in an aqueous solution and in rabbit plasma was investigated. Metabolites of nafiverine in blood, bile, and urine were determined quantitatively. The effectiveness of an intramuscular administration of nafiverine was comparable to that of an intravenous administration. One metabolite of nafiverine, N-(2-hydroxyethyl)-N'-[alpha-(naphthyl)propionyloxy-2-ethyl]piperazine, is a new compound.

Price and Availability

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Pricing updated 2020-08-09. Prices are subject to change without notice.

Nafiverine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 581125
Name: Nafiverine
CAS#: 5061-22-3
Chemical Formula: C30H22N4O4
Exact Mass: 502.1641
Molecular Weight: 502.53
Elemental Analysis: C, 71.70; H, 4.41; N, 11.15; O, 12.73

Synonym: Nafiverine; Nafiverinum; Nafiverina; Nafiverinum [INN-Latin]; UNII-WLT400RC9Q; EINECS 225-766-5;

IUPAC/Chemical Name: 2,2'-(1,4-Piperazindiyl)diethylbis(alpha-methyl-1-naphthalinacetat)


InChi Code: InChI=1S/C30H22N4O4/c35-27-25(28(36)32(22-15-7-2-8-16-22)31(27)21-13-5-1-6-14-21)26-29(37)33(23-17-9-3-10-18-23)34(30(26)38)24-19-11-4-12-20-24/h1-20,25-26H

SMILES Code: O=C(C1C2C(N(C3=CC=CC=C3)N(C4=CC=CC=C4)C2=O)=O)N(C5=CC=CC=C5)N(C6=CC=CC=C6)C1=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Naito S, Yamamoto T. Stability, absorption, excretion, and distribution of
nafiverine. J Pharm Sci. 1975 Feb;64(2):253-8. PubMed PMID: 1127581.

2: Ramu A, Ramu N. Reversal of multidrug resistance by bis(phenylalkyl)amines and
structurally related compounds. Cancer Chemother Pharmacol. 1994;34(5):423-30.
PubMed PMID: 8070010.