MS37452
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562266

CAS#: 423748-02-1

Description: MS37452 is a modulator of methyl-lysine. It acts by inducing transcriptional derepression of p16/CDKN2A by disrupting CBX7ChD binding to H3K27me3 at the INK4A/ARF locus in PC3 prostate cancer cells.


Chemical Structure

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MS37452
CAS# 423748-02-1

Theoretical Analysis

MedKoo Cat#: 562266
Name: MS37452
CAS#: 423748-02-1
Chemical Formula: C22H26N2O5
Exact Mass: 398.1842
Molecular Weight: 398.45
Elemental Analysis: C, 66.32; H, 6.58; N, 7.03; O, 20.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MS37452; MS-37452; MS 37452; MS452; MS-452; MS 452;

IUPAC/Chemical Name: 1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone

InChi Key: LUMCNRKHZRYQOV-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H26N2O5/c1-16-6-4-7-17(14-16)29-15-20(25)23-10-12-24(13-11-23)22(26)18-8-5-9-19(27-2)21(18)28-3/h4-9,14H,10-13,15H2,1-3H3

SMILES Code: CC1=CC(OCC(N2CCN(C(C3=CC=CC(OC)=C3OC)=O)CC2)=O)=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 398.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ren C, Morohashi K, Plotnikov AN, Jakoncic J, Smith SG, Li J, Zeng L, Rodriguez Y, Stojanoff V, Walsh M, Zhou MM. Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain. Chem Biol. 2015 Feb 19;22(2):161-8. doi: 10.1016/j.chembiol.2014.11.021. Epub 2015 Feb 5. PubMed PMID: 25660273; PubMed Central PMCID: PMC4336573.