Mulberroside A
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MedKoo CAT#: 562262

CAS#: 102841-42-9

Description: Mulberroside A is an anti-tyrosinase agent from Morus alba L.


Chemical Structure

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Mulberroside A
CAS# 102841-42-9

Theoretical Analysis

MedKoo Cat#: 562262
Name: Mulberroside A
CAS#: 102841-42-9
Chemical Formula: C26H32O14
Exact Mass: 568.1792
Molecular Weight: 568.52
Elemental Analysis: C, 54.93; H, 5.67; O, 39.40

Price and Availability

Size Price Availability Quantity
5.0mg USD 215.0 2 Weeks
10.0mg USD 350.0 2 Weeks
25.0mg USD 575.0 2 Weeks
50.0mg USD 1000.0 2 Weeks
100.0mg USD 1750.0 2 Weeks
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Synonym: Mulberroside A; Mulberroside-A;

IUPAC/Chemical Name: (2S,3R,4S,5S,6R)-2-[3-Hydroxy-4-[(E)-2-[3-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

InChi Key: HPSWAEGGWLOOKT-VUNDNAJOSA-N

InChi Code: InChI=1S/C26H32O14/c27-9-17-19(31)21(33)23(35)25(39-17)37-14-4-3-12(16(30)8-14)2-1-11-5-13(29)7-15(6-11)38-26-24(36)22(34)20(32)18(10-28)40-26/h1-8,17-36H,9-10H2/b2-1+/t17-,18-,19-,20-,21+,22+,23-,24-,25-,26-/m1/s1

SMILES Code: O[C@H]1[C@H](OC2=CC=C(/C=C/C3=CC(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)=CC(O)=C3)C(O)=C2)O[C@H](CO)[C@@H](O)[C@@H]1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 568.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Li J, Bai Y, Bai Y, Zhu R, Liu W, Cao J, An M, Tan Z, Chang YX. Pharmacokinetics of Caffeic Acid, Ferulic Acid, Formononetin, Cryptotanshinone, and Tanshinone IIA after Oral Administration of Naoxintong Capsule in Rat by HPLC-MS/MS. Evid Based Complement Alternat Med. 2017;2017:9057238. doi: 10.1155/2017/9057238. Epub 2017 Jul 5. PubMed PMID: 28757891; PubMed Central PMCID: PMC5516711.

2: He XR, Han SY, Li XH, Zheng WX, Pang LN, Jiang ST, Li PP. Chinese medicine Bu-Fei decoction attenuates epithelial-mesenchymal transition of non-small cell lung cancer via inhibition of transforming growth factor β1 signaling pathway in vitro and in vivo. J Ethnopharmacol. 2017 May 23;204:45-57. doi: 10.1016/j.jep.2017.04.008. Epub 2017 Apr 12. PubMed PMID: 28412214.

3: Chaita E, Lambrinidis G, Cheimonidi C, Agalou A, Beis D, Trougakos I, Mikros E, Skaltsounis AL, Aligiannis N. Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood. Molecules. 2017 Mar 23;22(4). pii: E514. doi: 10.3390/molecules22040514. PubMed PMID: 28333105.

4: Wang C, Zhi S, Liu C, Xu F, Zhao A, Wang X, Ren Y, Li Z, Yu M. Characterization of Stilbene Synthase Genes in Mulberry (Morus atropurpurea) and Metabolic Engineering for the Production of Resveratrol in Escherichia coli. J Agric Food Chem. 2017 Mar 1;65(8):1659-1668. doi: 10.1021/acs.jafc.6b05212. Epub 2017 Feb 14. PubMed PMID: 28168876.

5: Li Y, Huang L, Sun J, Wei X, Wen J, Zhong G, Huang M, Bi H. Mulberroside A suppresses PXR-mediated transactivation and gene expression of P-gp in LS174T cells. J Biochem Mol Toxicol. 2017 May;31(5). doi: 10.1002/jbt.21884. Epub 2016 Dec 5. PubMed PMID: 27918128.

6: Komaikul J, Kitisripanya T, Tanaka H, Sritularak B, Putalun W. Enhanced Mulberroside A Production from Cell Suspension and Root Cultures of Morus alba Using Elicitation. Nat Prod Commun. 2015 Jul;10(7):1253-6. PubMed PMID: 26411024.

7: Liu MF, Xie MP, Li L, Lu AQ, Shi JG, Wang SJ. [Quality standard study on Mori Cortex liquid extract]. Zhongguo Zhong Yao Za Zhi. 2015 May;40(10):1850-4. Chinese. PubMed PMID: 26390636.

8: Inyai C, Komaikul J, Kitisripanya T, Tanaka H, Sritularak B, Putalun W. Development of a Rapid Immunochromatographic Strip Test for the Detection of Mulberroside A. Phytochem Anal. 2015 Nov-Dec;26(6):423-7. doi: 10.1002/pca.2576. Epub 2015 Jun 11. PubMed PMID: 26096098.

9: Ko JA, Park JY, Kwon HJ, Ryu YB, Jeong HJ, Park SJ, Kim CY, Oh HM, Park CS, Lim YH, Kim D, Rho MC, Lee WS, Kim YM. Purification and functional characterization of the first stilbene glucoside-specific β-glucosidase isolated from Lactobacillus kimchi. Enzyme Microb Technol. 2014 Dec;67:59-66. doi: 10.1016/j.enzmictec.2014.09.001. Epub 2014 Sep 16. PubMed PMID: 25442950.

10: Wang S, Liu XM, Zhang J, Zhang YQ. An efficient preparation of mulberroside a from the branch bark of mulberry and its effect on the inhibition of tyrosinase activity. PLoS One. 2014 Oct 9;9(10):e109396. doi: 10.1371/journal.pone.0109396. eCollection 2014. PubMed PMID: 25299075; PubMed Central PMCID: PMC4192315.

11: Wang CP, Zhang LZ, Li GC, Shi YW, Li JL, Zhang XC, Wang ZW, Ding F, Liang XM. Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. J Neurosci Res. 2014 Jul;92(7):944-54. doi: 10.1002/jnr.23374. Epub 2014 Mar 31. PubMed PMID: 24687774.

12: Li Y, Huang L, Zeng X, Zhong G, Ying M, Huang M, Bi H. Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B. Chem Biol Interact. 2014 Apr 25;213:44-50. doi: 10.1016/j.cbi.2014.02.004. Epub 2014 Feb 14. PubMed PMID: 24530447.

13: Zhou J, Li SX, Yan XP, Ji M, Guo XY, Huang D, Zheng QY. [Comparative and correlational studies on contents of stilbenes in different portions of mulberry]. Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3261-4. Chinese. PubMed PMID: 24422388.

14: Jo SP, Kim JK, Lim YH. Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet. Food Chem Toxicol. 2014 Mar;65:213-8. doi: 10.1016/j.fct.2013.12.040. Epub 2014 Jan 7. PubMed PMID: 24407019.

15: Zhou J, Li SX, Wang W, Guo XY, Lu XY, Yan XP, Huang D, Wei BY, Cao L. Variations in the levels of mulberroside A, oxyresveratrol, and resveratrol in mulberries in different seasons and during growth. ScientificWorldJournal. 2013 Aug 19;2013:380692. doi: 10.1155/2013/380692. eCollection 2013. PubMed PMID: 24023529; PubMed Central PMCID: PMC3760103.

16: Shi YW, Wang CP, Wang X, Zhang YL, Liu L, Wang RW, Ye JF, Hu LS, Kong LD. Uricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic mice. J Ethnopharmacol. 2012 Oct 11;143(3):896-904. doi: 10.1016/j.jep.2012.08.023. Epub 2012 Aug 29. PubMed PMID: 22967667.

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19: Mei M, Ruan JQ, Wu WJ, Zhou RN, Lei JP, Zhao HY, Yan R, Wang YT. In vitro pharmacokinetic characterization of mulberroside A, the main polyhydroxylated stilbene in mulberry (Morus alba L.), and its bacterial metabolite oxyresveratrol in traditional oral use. J Agric Food Chem. 2012 Mar 7;60(9):2299-308. doi: 10.1021/jf204495t. Epub 2012 Feb 22. PubMed PMID: 22225542.

20: Park KT, Kim JK, Hwang D, Yoo Y, Lim YH. Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation. Food Chem Toxicol. 2011 Dec;49(12):3038-45. doi: 10.1016/j.fct.2011.09.008. Epub 2011 Sep 16. PubMed PMID: 21946069.