PDE7 inhibitor S14

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MedKoo CAT#: 562239

CAS#: 18741-24-7

Description: PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor. It acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element binding protein (CREB) pathway, exerting neuroprotection in an Alzheimer's disease (AD) model.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-06-03. Prices are subject to change without notice.

PDE7 inhibitor S14 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 10 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 562239
Name: PDE7 inhibitor S14
CAS#: 18741-24-7
Chemical Formula: C14H10N2OS
Exact Mass: 254.0514
Molecular Weight: 254.3
Elemental Analysis: C, 66.12; H, 3.96; N, 11.02; O, 6.29; S, 12.61

Synonym: PDE7 inhibitor S14; PDE7 inhibitor-S14; S14;

IUPAC/Chemical Name: 3-Phenyl-2-sulfanylquinazolin-4(3H)-one


InChi Code: InChI=1S/C14H10N2OS/c17-13-11-8-4-5-9-12(11)15-14(18)16(13)10-6-2-1-3-7-10/h1-9H,(H,15,18)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Bartolome F, de la Cueva M, Pascual C, Antequera D, Fernandez T, Gil C, Martinez A, Carro E. Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition. Alzheimers Res Ther. 2018 Feb 20;10(1):24. doi: 10.1186/s13195-018-0352-4. PubMed PMID: 29458418; PubMed Central PMCID: PMC5819290.

2: Morales-Garcia JA, Echeverry-Alzate V, Alonso-Gil S, Sanz-SanCristobal M, Lopez-Moreno JA, Gil C, Martinez A, Santos A, Perez-Castillo A. Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo. Stem Cells. 2017 Feb;35(2):458-472. doi: 10.1002/stem.2480. Epub 2016 Sep 16. PubMed PMID: 27538853.

3: Morales-Garcia JA, Alonso-Gil S, Gil C, Martinez A, Santos A, Perez-Castillo A. Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats. Stem Cells Transl Med. 2015 Jun;4(6):564-75. doi: 10.5966/sctm.2014-0277. Epub 2015 Apr 29. PubMed PMID: 25925836; PubMed Central PMCID: PMC4449102.

4: Perez-Gonzalez R, Pascual C, Antequera D, Bolos M, Redondo M, Perez DI, Pérez-Grijalba V, Krzyzanowska A, Sarasa M, Gil C, Ferrer I, Martinez A, Carro E. Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease. Neurobiol Aging. 2013 Sep;34(9):2133-45. doi: 10.1016/j.neurobiolaging.2013.03.011. Epub 2013 Apr 9. PubMed PMID: 23582662.