WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581110
CAS#: 71247-78-4
Description: Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells. Salaspermic acid, a new triterpene acid isolated from Salacia macrosperma Wight, has been shown to be 24-hydroxy-3-oxofriedelan-29-oic acid hemiacetal (IIIa) on the basis of spectral and chemical properties. The structure has been confirmed by an X-ray study of compound (VII) obtained from the acid by a sequence involving the enlargement of ring E.
MedKoo Cat#: 581110
Name: Salaspermic acid
CAS#: 71247-78-4
Chemical Formula: C30H48O4
Exact Mass: 472.3553
Molecular Weight: 472.71
Elemental Analysis: C, 76.23; H, 10.24; O, 13.54
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Synonym: Salaspermic acid; (3beta,20alpha)-3,24-Epoxy-3-hydroxy-D:A-friedooleanan-29-oic acid;
IUPAC/Chemical Name: (3S,5aR,7aS,7bS,9aS,12R,13aS,13bR,15aR,15bS,16R)-3-hydroxy-7b,9a,12,13b,15a,16-hexamethylicosahydro-5H-3,5a-methanochryseno[2,1-c]oxepine-12-carboxylic acid
InChi Key: ZXENWDWQTWYUGY-FSTDTXBSSA-N
InChi Code: InChI=1S/C30H48O4/c1-19-29-9-7-20-26(4,21(29)8-10-30(19,33)34-18-29)14-16-28(6)22-17-25(3,23(31)32)12-11-24(22,2)13-15-27(20,28)5/h19-22,33H,7-18H2,1-6H3,(H,31,32)/t19-,20+,21+,22+,24-,25-,26-,27+,28-,29+,30+/m1/s1
SMILES Code: O=C(O)[C@@]1(C)C[C@@H]2[C@](CC[C@]3(C)[C@@H]4CC[C@]56[C@@H](C)[C@](CC[C@@H]35)(OC6)O)(C)[C@@]4(C)CC[C@@]2(C)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 472.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Ngassapa O, Soejarto DD, Pezzuto JM, Farnsworth NR. Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea. J Nat Prod. 1994 Jan;57(1):1-8. PubMed PMID: 8158155.
2: Wang KW, Hu XL, Shen LQ, Pan YJ. [Study on triterpenes of Microtropis tiflora]. Zhongguo Zhong Yao Za Zhi. 2007 Aug;32(15):1539-41. Chinese. PubMed PMID: 17972583.
3: Chen K, Shi Q, Kashiwada Y, Zhang DC, Hu CQ, Jin JQ, Nozaki H, Kilkuskie RE, Tramontano E, Cheng YC, et al. Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds. J Nat Prod. 1992 Mar;55(3):340-6. PubMed PMID: 1375626.
4: Zhang C, Yan Z, Chen Y, Zhang Y, Lü X. [Studies on triterpenoids of total glucosides of tripterygium wilfordii]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1994 Dec;16(6):466-8. Chinese. PubMed PMID: 7720147.
