ML204 HCl

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MedKoo CAT#: 555185

CAS#: 2070015-10-8 (HCl)

Description: ML204 is a novel and potential TRPC4 Channel inhibitor. ML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. ML204 represents an excellent novel tool for investigation of TRPC4 channel function and may facilitate the development of therapeutics targeted to TRPC4.

Price and Availability

Size Price Shipping out time Quantity
500mg USD 950 2 Weeks
1g USD 1450 2 Weeks
2g USD 2450 2 Weeks
5g USD 3850 2 Weeks
10g USD 5950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

ML204 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555185
Name: ML204 HCl
CAS#: 2070015-10-8 (HCl)
Chemical Formula: C15H19ClN2
Exact Mass:
Molecular Weight: 262.781
Elemental Analysis: C, 68.56; H, 7.29; Cl, 13.49; N, 10.66

Related CAS #: 5465-86-1 (free base)   2070015-10-8 (HCl)    

Synonym: ML204 HCl; ML204 hydrochloride; ML-204; ML204.

IUPAC/Chemical Name: 4-Methyl-2-(1-piperidinyl)quinoline hydrochloride


InChi Code: InChI=1S/C15H18N2.ClH/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14;/h3-4,7-8,11H,2,5-6,9-10H2,1H3;1H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Lindström JB, Pierce NT, Latz MI. Role of TRP Channels in Dinoflagellate Mechanotransduction. Biol Bull. 2017 Oct;233(2):151-167. doi: 10.1086/695421. Epub 2018 Jan 3. PubMed PMID: 29373067.

2: Wang X, Dande RR, Yu H, Samelko B, Miller RE, Altintas MM, Reiser J. TRPC5 Does Not Cause or Aggravate Glomerular Disease. J Am Soc Nephrol. 2018 Feb;29(2):409-415. doi: 10.1681/ASN.2017060682. Epub 2017 Oct 23. PubMed PMID: 29061651; PubMed Central PMCID: PMC5791075.

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5: Griffin CS, Bradley E, Dudem S, Hollywood MA, McHale NG, Thornbury KD, Sergeant GP. Muscarinic Receptor Induced Contractions of the Detrusor are Mediated by Activation of TRPC4 Channels. J Urol. 2016 Dec;196(6):1796-1808. doi: 10.1016/j.juro.2016.05.108. Epub 2016 Jun 7. PubMed PMID: 27287524.

6: Gómez M, González A, Sáez CA, Moenne A. Copper-Induced Membrane Depolarizations Involve the Induction of Mosaic TRP Channels, Which Activate VDCC Leading to Calcium Increases in Ulva compressa. Front Plant Sci. 2016 Jun 14;7:754. doi: 10.3389/fpls.2016.00754. eCollection 2016. PubMed PMID: 27379106; PubMed Central PMCID: PMC4905984.

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8: Zhang L, Kolaj M, Renaud LP. Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. Neuroscience. 2016 May 13;322:308-19. doi: 10.1016/j.neuroscience.2016.02.047. Epub 2016 Feb 26. PubMed PMID: 26924019.

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10: Zhao PY, Gan G, Peng S, Wang SB, Chen B, Adelman RA, Rizzolo LJ. TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2015 Mar 3;56(3):1916-23. doi: 10.1167/iovs.14-15738. PubMed PMID: 25736794; PubMed Central PMCID: PMC4364639.

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