PYD-106 | CAS#1560894-05-4 | NMDA PAM

PYD-106
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555181

CAS#: 1560894-05-4

Description: PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator.

Chemical Structure

PYD-106

CAS# 1560894-05-4

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 555181
Name: PYD-106
CAS#: 1560894-05-4
Chemical Formula: C25H24N2O5
Exact Mass: 432.17
Molecular Weight: 432.480
Elemental Analysis: C, 69.43; H, 5.59; N, 6.48; O, 18.50

Price and Availability

Size	Price	Availability
1mg	USD 230	2 Weeks
5mg	USD 490	2 Weeks
10mg	USD 825	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: PYD-106; PYD 106; PYD106.

IUPAC/Chemical Name: Methyl 4-(3-acetyl-4-hydroxy-1-(2-(2-methyl-1H-indol-3-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

InChi Key: LIFGURQFZLMSDE-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H24N2O5/c1-14-18(19-6-4-5-7-20(19)26-14)12-13-27-22(21(15(2)28)23(29)24(27)30)16-8-10-17(11-9-16)25(31)32-3/h4-11,22,26,29H,12-13H2,1-3H3

SMILES Code: O=C(OC)C1=CC=C(C(C(C(C)=O)=C2O)N(CCC3=C(C)NC4=C3C=CC=C4)C2=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	PYD-106 enhances NR2C subunit-containing NMDA receptor responses in HEK293 cells (EC50 = 13 µM) and selectively targets these receptors over others like NR2A, NR2B, and NR2D.
In vitro activity:	In cultured HEK-293 cells, PYD-106, at a concentration of 30 μM, showed no effects on receptor types such as GluN2A, GluN2B, and GluN2D, as well as AMPA and kainate receptors. When coapplied with glutamate and glycine, PYD-106 at 50 μM significantly enhanced the responses of GluN1/GluN2C NMDA receptors in HEK-293 cells, indicating its positive allosteric modulatory effects. Reference: Mol Pharmacol. 2014 Nov;86(5):548-60. https://pubmed.ncbi.nlm.nih.gov/25205677/
In vivo activity:	To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 432.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9. PMID: 25205677; PMCID: PMC4201136. 2. Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S. Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat Struct Mol Biol. 2023 May;30(5):629-639. doi: 10.1038/s41594-023-00959-z. Epub 2023 Mar 23. PMID: 36959261.
In vitro protocol:	1. Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9. PMID: 25205677; PMCID: PMC4201136. 2. Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S. Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat Struct Mol Biol. 2023 May;30(5):629-639. doi: 10.1038/s41594-023-00959-z. Epub 2023 Mar 23. PMID: 36959261.
In vivo protocol:	To be determined

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong
KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB. The
Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric
Modulators Bound to the NMDA Receptor. Mol Pharmacol. 2018 Feb;93(2):141-156.
doi: 10.1124/mol.117.110940. Epub 2017 Dec 14. PubMed PMID: 29242355; PubMed
Central PMCID: PMC5767683.

2: Hackos DH, Hanson JE. Diverse modes of NMDA receptor positive allosteric
modulation: Mechanisms and consequences. Neuropharmacology. 2017 Jan;112(Pt
A):34-45. doi: 10.1016/j.neuropharm.2016.07.037. Epub 2016 Jul 30. Review. PubMed
PMID: 27484578.

3: Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC,
Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of
action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol
Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9.
PubMed PMID: 25205677; PubMed Central PMCID: PMC4201136.

Your view history

PYD-106 featured