Talampicillin hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341109

CAS#: 39878-70-1

Description: Talampicillin hydrochloride is a biochemical.


Chemical Structure

img
Talampicillin hydrochloride
CAS# 39878-70-1

Theoretical Analysis

MedKoo Cat#: 341109
Name: Talampicillin hydrochloride
CAS#: 39878-70-1
Chemical Formula: C24H24ClN3O6S
Exact Mass: 517.11
Molecular Weight: 517.981
Elemental Analysis: C, 55.65; H, 4.67; Cl, 6.84; N, 8.11; O, 18.53; S, 6.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Talampicillin hydrochloride; BRL 8988.

IUPAC/Chemical Name: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, monohydrochloride, (2S-(2alpha,5alpha,6beta(S*)))-

InChi Key: PAZSYTCTHYSIAO-GVMCPMFUSA-N

InChi Code: InChI=1S/C24H23N3O6S.ClH/c1-24(2)17(22(31)33-23-14-11-7-6-10-13(14)21(30)32-23)27-19(29)16(20(27)34-24)26-18(28)15(25)12-8-4-3-5-9-12;/h3-11,15-17,20,23H,25H2,1-2H3,(H,26,28);1H/t15-,16-,17+,20-,23-;/m1./s1

SMILES Code: O1[C@@H](c2c(C1=O)cccc2)OC([C@H]1C(S[C@H]2N1C([C@H]2NC([C@H](N)c1ccccc1)=O)=O)(C)C)=O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 517.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Pawełczyk E, Płotkowiak Z, Helska M. Kinetics of talampicillin decomposition in solutions. Acta Pol Pharm. 2002 Jan-Feb;59(1):25-9. PubMed PMID: 12026108.

2: Pawełczyk E, Płotkowiak Z, Helska M. Kinetics of thermal decomposition of talampicillin hydrochloride in the solid state. Pharmazie. 2000 May;55(5):390-1. PubMed PMID: 11828623.

3: Yoshii T, Yoshikawa T, Furudoi S, Yoshioka A, Ohtsuka Y, Komori T. Evaluation of oral antimicrobial agent levels in tooth extraction sites. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jun;91(6):643-8. PubMed PMID: 11402275.

4: Ensink JM, Vulto AG, van Miert AS, Tukker JJ, Winkel MB, Fluitman MA. Oral bioavailability and in vitro stability of pivampicillin, bacampicillin, talampicillin, and ampicillin in horses. Am J Vet Res. 1996 Jul;57(7):1021-4. PubMed PMID: 8807014.

5: Imayama S, Fukuda H, Hori Y. Drug eruptions following treatment with prodrugs: a review of the reported cases in Japan from 1984 to 1989. J Dermatol. 1991 May;18(5):277-80. Review. PubMed PMID: 1834713.

6: Nguyen NA, Mortada LM, Notari RE. Potential improvement in the shelf life of parenterals using the prodrug approach: bacampicillin and talampicillin hydrolysis kinetics and utilization time. Pharm Res. 1988 May;5(5):288-96. PubMed PMID: 3244638.

7: Akimoto Y, Nishimura H, Komiya M, Kaneko K, Fujii A, Tamura T. Ampicillin concentrations in human dental granuloma after a single oral administration of talampicillin. Antimicrob Agents Chemother. 1988 Apr;32(4):566-7. PubMed PMID: 3377465; PubMed Central PMCID: PMC172221.

8: Akimoto Y, Uda A, Omata H, Nishimura H, Komiya M, Kaneko K, Fujii A, Tamura T. Ampicillin concentrations in human serum and periodontal membrane following a single oral administration of talampicillin. Gen Pharmacol. 1988;19(4):515-6. PubMed PMID: 3410274.

9: Schönwald S, Beus I, Car V, Mahovlić V, Jeren T, Plavsić F, Brlić V. Bacampicillin, amoxycillin and talampicillin concentrations in bronchial secretions. Int J Clin Pharmacol Res. 1988;8(4):263-6. PubMed PMID: 3182115.

10: Yoshizawa M. [Influence of antibiotics on anti-inflammatory activity of anti-inflammatory drugs in simultaneous administration]. Nichidai Koko Kagaku. 1987 Mar;13(1):34-43. Japanese. PubMed PMID: 3506110.

11: Haginaka J, Wakai J. Liquid chromatographic determination of ampicillin and its metabolites in human urine by postcolumn alkaline degradation. J Pharm Pharmacol. 1987 Jan;39(1):5-8. PubMed PMID: 2880985.

12: Yamane N, Konnai T, Imoto T, Sekiguchi T, Tomita S, Ohta Y, Sasaki J. Blood levels and distribution of talampicillin and bacampicillin in NZW rabbits. Tokai J Exp Clin Med. 1986 May;11(2):91-9. PubMed PMID: 3564081.

13: Sjövall J, Huitfeldt B, Magni L, Nord CE. Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84. Review. PubMed PMID: 3547627.

14: Sasaki J, Gotoh J, Morihana K, Uematsu M, Takai H, Ohmura H, Abe H, Ikeshima K, Nishiyama K, Shiiki K, et al. [A comparative double blind study of lenampicillin and talampicillin in the treatment of oral infections]. Jpn J Antibiot. 1985 Sep;38(9):2453-80. Japanese. PubMed PMID: 3908737.

15: Fujita K, Sayama T, Abe S, Murayama T, Sugimoto M, Hara T. [The duration of antibacterial treatment following transurethral prostatectomy]. Jpn J Antibiot. 1985 Aug;38(8):2149-54. Japanese. PubMed PMID: 3852896.

16: Akimoto Y, Kaneko K, Fujii A, Tamura T. Ampicillin concentrations in human serum, gingiva, mandibular bone, dental follicle, and dental pulp following a single oral dose of talampicillin. J Oral Maxillofac Surg. 1985 Apr;43(4):270-6. PubMed PMID: 3856643.

17: Akimoto Y, Nishimura H, Komiya M, Shibata T, Kaneko K, Fujii A, Tamura T. Concentrations of ampicillin and cefadroxil in human serum and mixed saliva following a single oral administration of talampicillin and cefadroxil, and relationships between serum and mixed saliva concentrations. Gen Pharmacol. 1985;16(3):273-5. PubMed PMID: 4018542.

18: Benno Y, Mitsuoka T. Susceptibility of Bacteroides from swine abscesses to 13 antibiotics. Am J Vet Res. 1984 Dec;45(12):2631-3. PubMed PMID: 6524756.

19: Angelini NM, Ola FN. [In vitro hydrolysis of an ampicillin ester. I. Microbiologic evaluation]. Rev Latinoam Microbiol. 1983 Apr-Jun;25(2):109-12. Spanish. PubMed PMID: 6361948.

20: Mohanty KC, Roy RB. Treatment of uncomplicated gonorrhoea in women with talampicillin in a single oral 1.5 g dose. Br J Vener Dis. 1982 Jun;58(3):180-1. PubMed PMID: 7082979; PubMed Central PMCID: PMC1046040.