Taraxerol
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MedKoo CAT#: 562198

CAS#: 127-22-0

Description: Taraxerol is an inhibitor of NF-κB signaling. It acts by attenuating acute inflammation, and also shows PTP1B inhibitory activity.


Chemical Structure

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Taraxerol
CAS# 127-22-0

Theoretical Analysis

MedKoo Cat#: 562198
Name: Taraxerol
CAS#: 127-22-0
Chemical Formula: C30H50O
Exact Mass: 426.39
Molecular Weight: 426.720
Elemental Analysis: C, 84.44; H, 11.81; O, 3.75

Price and Availability

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10mg USD 480
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Synonym: Taraxerol; Alnulin; D-Friedoolean-14-en-3beta-ol;

IUPAC/Chemical Name: (3S,4aR,6aR,8aR,12aR,12bS,14aR,14bR)-4,4,6a,8a,11,11,12b,14b-octamethyl-1,2,3,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-icosahydropicen-3-ol

InChi Key: GGGUGZHBAOMSFJ-GADYQYKKSA-N

InChi Code: InChI=1S/C30H50O/c1-25(2)17-18-27(5)13-9-21-29(7)14-10-20-26(3,4)24(31)12-16-28(20,6)22(29)11-15-30(21,8)23(27)19-25/h9,20,22-24,31H,10-19H2,1-8H3/t20-,22+,23+,24-,27-,28-,29-,30+/m0/s1

SMILES Code: O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@]4(C)C3=CC[C@]5(C)[C@H]4CC(C)(C)CC5)C1(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 426.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mali PY, Panchal SS. Euphorbia neriifolia L.: Review on botany, ethnomedicinal uses, phytochemistry and biological activities. Asian Pac J Trop Med. 2017 May;10(5):430-438. doi: 10.1016/j.apjtm.2017.05.003. Epub 2017 May 18. Review. PubMed PMID: 28647179.

2: Lopes LG, Tavares GL, Thomaz LD, Sabino JR, Borges KB, Vieira PC, Veiga TA, de Souza Borges W. C15049. Taraxerol 4-Methoxybenzoate, an in vitro Inhibitor of Photosynthesis Isolated from Pavonia multiflora A. St-Hil. (Malvaceae). Chem Biodivers. 2016 Feb 10. doi: 10.1002/cbdv.00003. [Epub ahead of print] Review. PubMed PMID: 26864258.

3: Chinsembu KC. Tuberculosis and nature's pharmacy of putative anti-tuberculosis agents. Acta Trop. 2016 Jan;153:46-56. doi: 10.1016/j.actatropica.2015.10.004. Epub 2015 Oct 14. Review. PubMed PMID: 26464047.

4: Sharma K, Zafar R. Occurrence of taraxerol and taraxasterol in medicinal plants. Pharmacogn Rev. 2015 Jan-Jun;9(17):19-23. doi: 10.4103/0973-7847.156317. Review. PubMed PMID: 26009688; PubMed Central PMCID: PMC4441157.