Y 23684

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341072

CAS#: 118288-67-8

Description: Y-23684 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.


Chemical Structure

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Y 23684
CAS# 118288-67-8

Theoretical Analysis

MedKoo Cat#: 341072
Name: Y 23684
CAS#: 118288-67-8
Chemical Formula: C18H13ClN2O2S
Exact Mass: 356.0386
Molecular Weight: 356.824
Elemental Analysis: C, 60.59; H, 3.67; Cl, 9.93; N, 7.85; O, 8.97; S, 8.98

Size Price Shipping out time Quantity
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Pricing updated 2021-03-05. Prices are subject to change without notice.

Y 23684 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: Y 23684; Y-23684; Y23684.

IUPAC/Chemical Name: (1)Benzothiepino(5,4-c)pyridazin-3(2H)-one, 2-(4-chlorophenyl)-5,6-dihydro-, 7-oxide

InChi Key: WHMCSFWQVGJBGM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H13ClN2O2S/c19-13-5-7-14(8-6-13)21-17(22)11-12-9-10-24(23)16-4-2-1-3-15(16)18(12)20-21/h1-8,11H,9-10H2

SMILES Code: c1ccc2c(c1)-c3c(cc(=O)n(n3)c4ccc(cc4)Cl)CCS2=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 356.824 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ. Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands. Behav Pharmacol. 1999 Sep;10(5):483-95. PubMed PMID: 10780255.

2: Y 23684. Drugs R D. 1999 Jul;2(1):68-9. PubMed PMID: 10610289.

3: Griebel G, Perrault G, Sanger DJ. Differences in anxiolytic-like profile of two novel nonbenzodiazepine BZ (omega) receptor agonists on defensive behaviors of mice. Pharmacol Biochem Behav. 1999 Apr;62(4):689-94. PubMed PMID: 10208374.

4: Yasumatsu H, Morimoto Y, Yamamoto Y, Takehara S, Fukuda T, Nakao T, Setoguchi M. The pharmacological properties of Y-23684, a benzodiazepine receptor partial agonist. Br J Pharmacol. 1994 Apr;111(4):1170-8. PubMed PMID: 7913372; PubMed Central PMCID: PMC1910153.

5: Yakushiji T, Shirasaki T, Munakata M, Hirata A, Akaike N. Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurones. Br J Pharmacol. 1993 Jul;109(3):819-25. PubMed PMID: 8395299; PubMed Central PMCID: PMC2175650.

6: Samemoto H, Yamada I, Yata T, Ogawa K. Powder coating mixture of a novel anxiolytic, Y-23684: dissolution characteristics and bioavailability. Chem Pharm Bull (Tokyo). 1992 Apr;40(4):1007-10. PubMed PMID: 1356081.

7: Nakao T, Obata M, Yamaguchi Y, Marubayashi N, Ikeda K, Morimoto Y. Synthesis and biological activities of optical isomers of 2-(4-chlorophenyl)-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-o ne 7-oxide. Chem Pharm Bull (Tokyo). 1992 Jan;40(1):117-21. PubMed PMID: 1349512.

8: Nakao T, Obata M, Kawakami M, Morita K, Tanaka H, Morimoto Y, Takehara S, Yakushiji T, Tahara T. Studies on the synthesis of condensed pyridazine derivatives. IV. Synthesis and anxiolytic activity of 2-aryl-5,6-dihydro-(1)benzothiepino[5,4- c]pyridazin-3(2H)-ones and related compound. Chem Pharm Bull (Tokyo). 1991 Oct;39(10):2556-63. PubMed PMID: 1687209.