WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555162
CAS#: 1173154-32-9
Description: ALB-127158A, also known as ALB-127158(a), is a MCH1 antagonist for the treatment of obesity. Preclinical studies demonstrated that the compound produced significant weight loss in rodents. ALB-127158(a) may be a potential treatment for IBD. This example demonstrates how using data from the preclinical studies is possible to build decision points into an early clinical development plan that will allow early assessment of potential efficacy and allow timely go/no go decisions.
MedKoo Cat#: 555162
Name: ALB-127158A
CAS#: 1173154-32-9
Chemical Formula: C23H21FN4O2
Exact Mass: 404.1649
Molecular Weight: 404.4454
Elemental Analysis: C, 68.30; H, 5.23; F, 4.70; N, 13.85; O, 7.91
Synonym: ALB-127158A; ALB 127158A; ALB127158A; ALB-127158(a); ALB127158(a); ALB 127158(a); ALB-127158; ALB 127158; ALB127158;
IUPAC/Chemical Name: 2(1H)-Pyridinone, 4-[(5-fluoro-2-pyridinyl)methoxy]-1-(2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-7-yl)-
InChi Key: VUUUHLIHQHVLLE-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H21FN4O2/c1-27-21-6-8-25-13-20(21)19-5-4-17(10-22(19)27)28-9-7-18(11-23(28)29)30-14-16-3-2-15(24)12-26-16/h2-5,7,9-12,25H,6,8,13-14H2,1H3
SMILES Code: O=C1C=C(OCC2=NC=C(F)C=C2)C=CN1C3=CC4=C(C=C3)C(CNCC5)=C5N4C
1: Moore NA, Sargent BJ, Guzzo PR, Surman MD. From preclinical to clinical
development: the example of a novel treatment for obesity. Neurobiol Dis. 2014
Jan;61:47-54. doi: 10.1016/j.nbd.2013.07.009. Epub 2013 Jul 25. Review. PubMed
PMID: 23891728.
