I942 EPAC1 agonist

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562162

CAS#: 868145-09-9

Description: I942 EPAC1 agonist, also known as I942, is a first in class, isoform selective non-cyclic nucleotide (NCN) EPAC1 agonist.


Chemical Structure

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I942 EPAC1 agonist
CAS# 868145-09-9

Theoretical Analysis

MedKoo Cat#: 562162
Name: I942 EPAC1 agonist
CAS#: 868145-09-9
Chemical Formula: C20H19NO4S
Exact Mass: 369.1035
Molecular Weight: 369.43
Elemental Analysis: C, 65.02; H, 5.18; N, 3.79; O, 17.32; S, 8.68

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-03-05. Prices are subject to change without notice.

I942 EPAC1 agonist is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: I942; I-942; I 942; I942 EPAC1 agonist

IUPAC/Chemical Name: N-((2,4-Dimethylphenyl)sulfonyl)-2-(naphthalen-2-yloxy)acetamide

InChi Key: KCRXXSQZEZOCFM-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19NO4S/c1-14-7-10-19(15(2)11-14)26(23,24)21-20(22)13-25-18-9-8-16-5-3-4-6-17(16)12-18/h3-12H,13H2,1-2H3,(H,21,22)

SMILES Code: O=C(NS(=O)(C1=CC=C(C)C=C1C)=O)COC2=CC=C3C=CC=CC3=C2

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 369.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Barker G, Parnell E, van Basten B, Buist H, Adams DR, Yarwood SJ. The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation. J Cardiovasc Dev Dis. 2017 Dec 5;4(4). pii: E22. doi: 10.3390/jcdd4040022. Review. PubMed PMID: 29367551; PubMed Central PMCID: PMC5753123.

2: Parnell E, McElroy SP, Wiejak J, Baillie GL, Porter A, Adams DR, Rehmann H, Smith BO, Yarwood SJ. Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1. Sci Rep. 2017 Mar 22;7(1):294. doi: 10.1038/s41598-017-00455-7. PubMed PMID: 28331191; PubMed Central PMCID: PMC5428521.

3: Roland M, Everington S. Tackling the crisis in general practice. BMJ. 2016 Feb 17;352:i942. doi: 10.1136/bmj.i942. PubMed PMID: 26887896.