UMB-136

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MedKoo CAT#: 558274

CAS#: 2109805-83-4

Description: UMB-136 is a bromodomain BRD4 inhibitor. It acts by significantly inducing HIV-1 reactivation.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-31. Prices are subject to change without notice.

UMB-136 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 558274
Name: UMB-136
CAS#: 2109805-83-4
Chemical Formula: C24H27N5O2
Exact Mass: 417.2165
Molecular Weight: 417.51
Elemental Analysis: C, 69.04; H, 6.52; N, 16.77; O, 7.66


Synonym: UMB-136; UMB 136; UMB136;

IUPAC/Chemical Name: N-Cyclohexyl-2-(4-(3,5-dimethylisoxazol-4-yl)-2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-amine

InChi Key: JEWZSWPGZVIJJN-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H27N5O2/c1-15-22(16(2)31-28-15)17-9-10-19(20(13-17)30-3)23-24(26-18-7-5-4-6-8-18)29-12-11-25-14-21(29)27-23/h9-14,18,26H,4-8H2,1-3H3

SMILES Code: COC1=CC(C2=C(C)ON=C2C)=CC=C1C3=C(NC4CCCCC4)N5C(C=NC=C5)=N3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Huang H, Liu S, Jean M, Simpson S, Huang H, Merkley M, Hayashi T, Kong W, Rodríguez-Sánchez I, Zhang X, Yosief HO, Miao H, Que J, Kobie JJ, Bradner J, Santoso NG, Zhang W, Zhu J. A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association. Front Microbiol. 2017 Jun 7;8:1035. doi: 10.3389/fmicb.2017.01035. eCollection 2017. PubMed PMID: 28638377; PubMed Central PMCID: PMC5461361.