WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562144
Description: L458-BPyne is a γ-secretase modulator photoaffinity probe. It acts by identifying distinct allosteric binding sites on presenilin that can be exploited to reduce levels of pathogenic Aβ species.
MedKoo Cat#: 562144
Chemical Formula: C52H64N4O7
Exact Mass: 856.4775
Molecular Weight: 857.1
Elemental Analysis: C, 72.87; H, 7.53; N, 6.54; O, 13.07
This product is not in stock, which may be available by custom synthesis.
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Synonym: L458-BPyne; L458 BPyne; L458BPyne;
IUPAC/Chemical Name: tert-butyl ((2S,3R,5R)-6-(((S)-1-((S)-3-(4-benzoylphenyl)-2-(hex-5-yn-1-ylamino)propanamido)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate
InChi Key: NRKFVGLIZPQIHW-BDHQKZEVSA-N
InChi Code: InChI=1S/C52H64N4O7/c1-7-8-9-19-30-53-44(34-39-26-28-41(29-27-39)47(58)40-24-17-12-18-25-40)49(60)56-50(61)45(31-36(2)3)54-48(59)42(32-37-20-13-10-14-21-37)35-46(57)43(33-38-22-15-11-16-23-38)55-51(62)63-52(4,5)6/h1,10-18,20-29,36,42-46,53,57H,8-9,19,30-35H2,2-6H3,(H,54,59)(H,55,62)(H,56,60,61)/t42-,43+,44+,45+,46-/m1/s1
SMILES Code: O=C(OC(C)(C)C)N[C@H]([C@H](O)C[C@@H](CC1=CC=CC=C1)C(N[C@H](C(NC([C@@H](NCCCCC#C)CC2=CC=C(C(C3=CC=CC=C3)=O)C=C2)=O)=O)CC(C)C)=O)CC4=CC=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 857.1 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|