D21-2393
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581081

CAS#: 834919-19-6

Description: D21-2393 is known as Edoxaban 4-Carboxylic Acid. Subjects received a single-oral-dose of edoxaban 30-90 mg in each study occasion under fasting condition. Serial blood samples were collected to measure the plasma concentrations of edoxaban and its major active metabolite D21-2393. Meanwhile, PT, INR, aPTT were measured pre- and post-dose. Safety was assessed. 4. The effects of edoxaban on all pharmacodynamic biomarkers were concentration-dependent and linearly-correlated to plasma level of the compound. Minor bleeding was the most commonly reported adverse events.


Chemical Structure

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D21-2393
CAS# 834919-19-6

Theoretical Analysis

MedKoo Cat#: 581081
Name: D21-2393
CAS#: 834919-19-6
Chemical Formula: C22H25ClN6O5S
Exact Mass: 520.1296
Molecular Weight: 520.99
Elemental Analysis: C, 50.72; H, 4.84; Cl, 6.80; N, 16.13; O, 15.35; S, 6.15

Price and Availability

Size Price Availability Quantity
10.0mg USD 950.0 2 Weeks
25.0mg USD 2050.0 2 Weeks
50.0mg USD 3850.0 2 Weeks
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Synonym: D21-2393; D21 2393; UNII-IV344R972X; Edoxaban 4-Carboxylic Acid;

IUPAC/Chemical Name: Cyclohexanecarboxylic acid, 4-((2-((5-chloro-2-pyridinyl)amino)-2-oxoacetyl)amino)-3-(((4,5,6,7-tetrahydro-5-methylthiazolo(5,4-C)pyridin-2-yl)carbonyl)amino)-, (1S,3R,4S)-

InChi Key: QPYMJNYAASVNAP-CORIIIEPSA-N

InChi Code: InChI=1S/C22H25ClN6O5S/c1-29-7-6-14-16(10-29)35-21(27-14)20(32)26-15-8-11(22(33)34)2-4-13(15)25-18(30)19(31)28-17-5-3-12(23)9-24-17/h3,5,9,11,13,15H,2,4,6-8,10H2,1H3,(H,25,30)(H,26,32)(H,33,34)(H,24,28,31)/t11-,13-,15+/m0/s1

SMILES Code: O=C([C@@H]1C[C@@H](NC(C(S2)=NC3=C2CN(C)CC3)=O)[C@@H](NC(C(NC4=NC=C(Cl)C=C4)=O)=O)CC1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 520.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chen X, Liu D, Wu Y, Song H, Liu Y, Jiang J, Hu P. A single-dose study investigating the pharmacokinetics and pharmacodynamics of edoxaban at 30-90 mg in healthy Chinese volunteers. Xenobiotica. 2017 Jul;47(7):592-599. doi: 10.1080/00498254.2016.1207825. Epub 2016 Aug 25. PubMed PMID: 27560456.

2: Chen X, Liu D, Wu Y, Liu Y, Song H, Jiang J, Hu P. A single and multiple postprandial dose study investigating the pharmacokinetics and pharmacodynamics of edoxaban in healthy Chinese volunteers
. Int J Clin Pharmacol Ther. 2017 Mar;55(3):256-263. doi: 10.5414/CP202737. PubMed PMID: 28025966.

D21-2393

10.0mg / USD 950.0