Paramethasone | CAS#53-33-8 | glucocorticoid

Paramethasone
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584336

CAS#: 53-33-8

Description: Paramethasone is a glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than Hydrocortisone with supplementary Fludrocortisone.

Chemical Structure

Paramethasone

CAS# 53-33-8

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 584336
Name: Paramethasone
CAS#: 53-33-8
Chemical Formula: C22H29FO5
Exact Mass: 392.20
Molecular Weight: 392.467
Elemental Analysis: C, 67.33; H, 7.45; F, 4.84; O, 20.38

Price and Availability

Size	Price	Availability	Quantity
2mg	USD 345
25mg	USD 1650
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Paramethasone; CS 1483

IUPAC/Chemical Name: Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-

InChi Key: MKPDWECBUAZOHP-AFYJWTTESA-N

InChi Code: InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

SMILES Code: C[C@@]12[C@](C(CO)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Paramethasone is a glucocorticoid with the general properties of corticosteroids.
In vitro activity:	TBD
In vivo activity:	TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 392.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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1: López-Serrano MC, Moreno-Ancillo A, Contreras J, Ortega N, Cabañas R, Barranco P, Muñoz-Pereira M. Two cases of specific adverse reactions to systemic corticosteroids. J Investig Allergol Clin Immunol. 1996 Sep-Oct;6(5):324-7. PubMed PMID: 8959545.

2: Friedrich L, Wuppermann D, Zimmermann F. [Effect of high dosis of D-penicillamine and paramethasone on mechanical properties of rat connective tissue (author's transl)]. Arch Dermatol Forsch. 1975;252(2):161-6. German. PubMed PMID: 1147696.

3: Cortés-Gallegos V, Carranco A, Sojo I, Alonso R, Valenzuela-Duriet P. Effect of paramethasone acetate upon estrogen action. Fertil Steril. 1982 Mar;37(3):402-5. PubMed PMID: 7060790.

4: Montoro J, Valero A, Serra-Baldrich E, Amat P, Lluch M, Malet A. Anaphylaxis to paramethasone with tolerance to other corticosteroids. Allergy. 2000 Feb;55(2):197-8. PubMed PMID: 10726740.

5: Cortés-Gallegos V, Alonso R, Castañeda G, Sojo I, Carranco A, Cervantes C, Parra A. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic pituitary-gonadal axis. J Steroid Biochem. 1984 Jan;20(1):353-6. PubMed PMID: 6423900.

6: Cortés-Gallegos V, Alonso-Uriarte ME, Said LE, Cervantes C, Parra A. Effect of paramethasone acetate on women with secondary amenorrhea: a preliminary report. Fertil Steril. 1978 Apr;29(4):402-6. PubMed PMID: 77230.

7: Rovira E, García-Escrig M, Catalá J, García J. [Chronic adhesive arachnoiditis following epidural paramethasone]. Rev Neurol. 1997 Dec;25(148):2067-8. Spanish. PubMed PMID: 9528075.

8: JAUREGUIGUTIERREZ R, TREVINODELAPENA E. [PARAMETHASONE. CLINICAL EVALUATION IN 20 PATIENTS WITH RHEUMATOID ARTHRITIS TREATED FROM 6 TO 34 MONTHS WITHOUT INTERRUPTION]. Medicina (Mex). 1964 Feb 10;44:49-55. Spanish. PubMed PMID: 14143135.

9: Gum OB. A controlled study of two preparations, paramethasone, propoxyphene, and aspirin and propoxyphene and aspirin in the treatment of arthritis. Am J Med Sci. 1966 Mar;251(3):328-32. PubMed PMID: 5324359.

10: MATHIES H, RASPE J. [COMPARATIVE CLINICAL STUDIES WITH PARAMETHASONE AND PREDNISONE]. Arzneimittelforschung. 1963 Dec;13:1058-63. German. PubMed PMID: 14208677.

11: Wasek Z, Plusa T. [Clinical evaluation of triamcinolone and paramethasone in the treatment of chronic asthma]. Pneumonol Pol. 1976;44(1):49-53. Polish. PubMed PMID: 940780.

12: Montes Eeyes JS. [Treatment of sport injuries by using paramethasone acetate]. Rev Esp Reum Enferm Osteoartic. 1976;19(2):203-24. Spanish. PubMed PMID: 959639.

13: Bonomo I, Reis SS, Vieira FJ, Toledo AH, Barreto AC, Pascoal WR, Costa RM. [Clinical trial of paramethasone by intra-articular administration]. Hospital (Rio J). 1971 Jan;79(1):95-9. Portuguese. PubMed PMID: 5316658.

14: MATHIES H. [PARAMETHASONE IN THE THERAPY OF CHRONIC POLYARTHRITIS]. Med Monatsschr. 1964 Oct;18:465-7. German. PubMed PMID: 14334934.

15: Nakamura H, Matsushita K, Hata M, Sakaguchi H. Less toxic corticosteroid therapy in canine renal allografts. Keio J Med. 1978 Apr;27(1):15-21. PubMed PMID: 216844.

16: FURUKAWA W, TAKEUCHI T. [CLINICAL TRIAL OF PARAMETHASONE ACETATE IN PEDIATRICS]. Chiryo. 1964;46:780-4. Japanese. PubMed PMID: 14148039.

17: MIZRAJI M. [PARAMETHASONE IN THE TREATMENT OF SOME RHEUMATIC DISEASES]. Rev Esp Reum Enferm Osteoartic. 1963 Apr;10:122-6. Spanish. PubMed PMID: 14076943.

18: ROBLESGIL J, KATONA G. [4 YEARS' EXPERIENCE WITH PARAMETHASONE IN THE TREATMENT OF RHEUMATOID ARTHRITIS]. Arch Interam Rheumatol. 1964 Mar;7:104-19. Spanish. PubMed PMID: 14154181.

19: Desbrosses J. [Injectable paramethasone acetate in surgical practice]. Lyon Med. 1970 Nov 29;224(39):741-3. French. PubMed PMID: 5485437.

20: Davies GE, Thompson A. Effects of corticosteroid treatment and inflammation on the cellular content of blood and exudate in mice. J Pathol. 1975 Jan;115(1):17-26. PubMed PMID: 125317.

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