WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407881
Description: Y08060 is a potent and selective BET Inhibitor for Treatment of Prostate Cancer. Y08060 has IC50 values of 3.23 and 4.41 μM in inhibition of cell viability in the C4−2B and LNCaP cell lines, respectively. Y08060 effectively suppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines. In in vivo studies, 36 demonstrates a good PK profile with high oral bioavailability (61.54%) and is a promising lead compound for further prostate cancer drug development.
MedKoo Cat#: 407881
Chemical Formula: C18H19BrN2O6S
Exact Mass: 470.0147
Molecular Weight: 471.322
Elemental Analysis: C, 45.87; H, 4.06; Br, 16.95; N, 5.94; O, 20.37; S, 6.80
Y08060 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: Y08060; Y-08060; Y 08060.
IUPAC/Chemical Name: 5-Bromo-2-methoxy-N-(6-methoxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)benzenesulfonamide
InChi Key: BVPMJOFBUGYDAV-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H19BrN2O6S/c1-18(2)17(22)20-11-8-14(26-4)12(9-15(11)27-18)21-28(23,24)16-7-10(19)5-6-13(16)25-3/h5-9,21H,1-4H3,(H,20,22)
SMILES Code: O=S(C1=CC(Br)=CC=C1OC)(NC2=C(OC)C=C(N3)C(OC(C)(C)C3=O)=C2)=O
The following data is based on the product molecular weight 471.322 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer
Qiuping Xiang, Yan Zhang, Jiaguo Li, Xiaoqian Xue, Chao Wang, Ming Song, Cheng Zhang, Rui Wang, Chenchang Li, Chun Wu, Yulai Zhou, Xiaohong Yang, Guohui Li, Ke Ding, and Yong Xu
Publication Date (Web): February 13, 2018 (Letter)