Y08060

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407881

CAS#: Unknown

Description: Y08060 is a potent and selective BET Inhibitor for Treatment of Prostate Cancer. Y08060 has IC50 values of 3.23 and 4.41 μM in inhibition of cell viability in the C4−2B and LNCaP cell lines, respectively. Y08060 effectively suppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines. In in vivo studies, 36 demonstrates a good PK profile with high oral bioavailability (61.54%) and is a promising lead compound for further prostate cancer drug development.


Chemical Structure

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Y08060
CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 407881
Name: Y08060
CAS#: Unknown
Chemical Formula: C18H19BrN2O6S
Exact Mass: 470.0147
Molecular Weight: 471.322
Elemental Analysis: C, 45.87; H, 4.06; Br, 16.95; N, 5.94; O, 20.37; S, 6.80

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-03-06. Prices are subject to change without notice.

Y08060 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: Y08060; Y-08060; Y 08060.

IUPAC/Chemical Name: 5-Bromo-2-methoxy-N-(6-methoxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)benzenesulfonamide

InChi Key: BVPMJOFBUGYDAV-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H19BrN2O6S/c1-18(2)17(22)20-11-8-14(26-4)12(9-15(11)27-18)21-28(23,24)16-7-10(19)5-6-13(16)25-3/h5-9,21H,1-4H3,(H,20,22)

SMILES Code: O=S(C1=CC(Br)=CC=C1OC)(NC2=C(OC)C=C(N3)C(OC(C)(C)C3=O)=C2)=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 471.322 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer
Qiuping Xiang, Yan Zhang, Jiaguo Li, Xiaoqian Xue, Chao Wang, Ming Song, Cheng Zhang, Rui Wang, Chenchang Li, Chun Wu, Yulai Zhou, Xiaohong Yang, Guohui Li, Ke Ding, and Yong Xu
Publication Date (Web): February 13, 2018 (Letter)
DOI: 10.1021/acsmedchemlett.8b00003