WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571503
CAS#: 53164-05-9
Description: Acemetacin is a non-steroidal anti-inflammatory drug . In bioactive situations it biotransforms to indomethacin to act as an analgesic.
MedKoo Cat#: 571503
Name: Acemetacin
CAS#: 53164-05-9
Chemical Formula: C21H18ClNO6
Exact Mass: 415.0823
Molecular Weight: 415.83
Elemental Analysis: C, 60.66; H, 4.36; Cl, 8.53; N, 3.37; O, 23.09
Synonym: Acemetacin; Rantudil; K 708; K-708; K708
IUPAC/Chemical Name: 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester
InChi Key: FSQKKOOTNAMONP-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)
SMILES Code: O=C(OCC(O)=O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 415.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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20: Chávez-Piña AE, Vong L, McKnight W, Dicay M, Zanardo RC, Ortiz MI, Castañeda-Hernández G, Wallace JL. Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety. Br J Pharmacol. 2008 Nov;155(6):857-64. doi: 10.1038/bjp.2008.316. Epub 2008 Aug 11. PubMed PMID: 18695646; PubMed Central PMCID: PMC2597236.
