WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341046

CAS#: 61596-47-2

Description: Prolylleucine is a biochemical.

Chemical Structure

CAS# 61596-47-2

Theoretical Analysis

MedKoo Cat#: 341046
Name: Prolylleucine
CAS#: 61596-47-2
Chemical Formula: C19H26N2O5
Exact Mass: 362.18
Molecular Weight: 362.426
Elemental Analysis: C, 62.97; H, 7.23; N, 7.73; O, 22.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Prolylleucine

IUPAC/Chemical Name: D-Leucine, N-(1-((phenylmethoxy)carbonyl)-L-prolyl)-


InChi Code: InChI=1S/C19H26N2O5/c1-13(2)11-15(18(23)24)20-17(22)16-9-6-10-21(16)19(25)26-12-14-7-4-3-5-8-14/h3-5,7-8,13,15-16H,6,9-12H2,1-2H3,(H,20,22)(H,23,24)/t15-,16+/m1/s1

SMILES Code: C([C@H](NC([C@H]1N(CCC1)C(=O)OCc1ccccc1)=O)CC(C)C)(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 362.426000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Gao C, Lin L, Long B, Chen Y, He B, Sun H, Huang R. A new diketopiperazine from the gorgonian coral Menella kanisa. Nat Prod Res. 2014;28(7):473-6. doi: 10.1080/14786419.2013.879134. Epub 2014 Jan 31. PubMed PMID: 24479814. 2: Parveen S, Arjmand F, Mohapatra DK. Zinc(II) complexes of Pro-Gly and Pro-Leu dipeptides: synthesis, characterization, in vitro DNA binding and cleavage studies. J Photochem Photobiol B. 2013 Sep 5;126:78-86. doi: 10.1016/j.jphotobiol.2013.07.009. Epub 2013 Jul 17. PubMed PMID: 23911763. 3: Kravchenko EV, Ol'gomets LM. [Influence of changes in the state of brain neurotransmitter and peptidergic systems on circadian rhythms and behavior of rats]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2012 Jul-Aug;62(4):453-64. Russian. PubMed PMID: 23035562. 4: Hebert EM, Mamone G, Picariello G, Raya RR, Savoy G, Ferranti P, Addeo F. Characterization of the pattern of alphas1- and beta-casein breakdown and release of a bioactive peptide by a cell envelope proteinase from Lactobacillus delbrueckii subsp. lactis CRL 581. Appl Environ Microbiol. 2008 Jun;74(12):3682-9. doi: 10.1128/AEM.00247-08. Epub 2008 Apr 18. PubMed PMID: 18424544; PubMed Central PMCID: PMC2446539. 5: Shinkai T, Müller DJ, De Luca V, Shaikh S, Matsumoto C, Hwang R, King N, Trakalo J, Potapova N, Zai G, Hori H, Ohmori O, Meltzer HY, Nakamura J, Kennedy JL. Genetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia. Psychiatry Res. 2006 Feb 28;141(2):123-8. Epub 2006 Jan 18. PubMed PMID: 16413612. 6: Karoyan P, Quancard J, Vaissermann J, Chassaing G. Amino-zinc-enolate carbometalation reactions: application to ring closure of terminally substituted olefin for the asymmetric synthesis of cis- and trans-3-prolinoleucine. J Org Chem. 2003 Mar 21;68(6):2256-65. PubMed PMID: 12636389. 7: Guédon E, Renault P, Ehrlich SD, Delorme C. Transcriptional pattern of genes coding for the proteolytic system of Lactococcus lactis and evidence for coordinated regulation of key enzymes by peptide supply. J Bacteriol. 2001 Jun;183(12):3614-22. PubMed PMID: 11371525; PubMed Central PMCID: PMC95238. 8: Meijer W, Marugg JD, Hugenholtz J. Regulation of Proteolytic Enzyme Activity in Lactococcus lactis. Appl Environ Microbiol. 1996 Jan;62(1):156-61. PubMed PMID: 16535207; PubMed Central PMCID: PMC1388749. 9: Marugg JD, Meijer W, van Kranenburg R, Laverman P, Bruinenberg PG, de Vos WM. Medium-dependent regulation of proteinase gene expression in Lactococcus lactis: control of transcription initiation by specific dipeptides. J Bacteriol. 1995 Jun;177(11):2982-9. PubMed PMID: 7768792; PubMed Central PMCID: PMC176983. 10: Kulikov NV, Basok SS, Lukyanenko NG. Studies on the carbodiimide-mediated model couplings of Z-Pro-Leu-OH with benzoaza-15-crown-5. Int J Pept Protein Res. 1993 Jul;42(1):20-3. PubMed PMID: 8370639. 11: Codini M, Palmerini CA, Fini C, Lucarelli C, Floridi A. High-performance liquid chromatographic method for the determination of prolyl peptides in urine. J Chromatogr. 1991 Jan 4;536(1-2):337-41. PubMed PMID: 2050773. 12: de Roux N, Chadeuf G, Molho-Sabatier P, Plouin PF, Aiach M. Clinical and biochemical characterization of antithrombin III Franconville, a variant with Pro 41 Leu mutation. Br J Haematol. 1990 Jun;75(2):222-7. PubMed PMID: 2372510. 13: Panneerselvam K, Chacko KK. Structure and conformation of peptides involving prolyl residue. IV. L-Prolyl-L-leucine monohydrate. Int J Pept Protein Res. 1990 May;35(5):460-4. PubMed PMID: 2376471. 14: Kovács GL, Sarnyai Z, Izbéki F, Szabó G, Telegdy G, Barth T, Jost K, Brtnik F. Effects of oxytocin-related peptides on acute morphine tolerance: opposite actions by oxytocin and its receptor antagonists. J Pharmacol Exp Ther. 1987 May;241(2):569-74. PubMed PMID: 3033220. 15: Szabó G, Kovács GL, Székeli S, Baláspiri L, Telegdy G. C-terminal fragments of oxytocin (prolyl-leucyl-glycinamide and Z-prolyl-D-leucine) attenuate the development of tolerance to ethanol. Acta Physiol Hung. 1987;69(1):115-22. PubMed PMID: 2884803. 16: Kovács GL, Horváth Z, Sarnyai Z, Faludi M, Telegdy G. Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain. Neuropharmacology. 1985 May;24(5):413-9. PubMed PMID: 2991800. 17: Kovács GL, Izbéki F, Horváth Z, Telegdy G. Effects of oxytocin and a derivative (Z-prolyl-D-leucine) on morphine tolerance/withdrawal are mediated by the limbic system. Behav Brain Res. 1984 Oct;14(1):1-8. PubMed PMID: 6542796. 18: Kovács GL, Telegdy G, Hódi K. Drugs affecting brain dopamine interfere with the effect of Z-prolyl-D-leucine on morphine withdrawal. Pharmacol Biochem Behav. 1984 Sep;21(3):345-8. PubMed PMID: 6541792. 19: Chipkin RE, Latranyi MB. Effect of cyclo-leucyl-glycine in the rat yeast-paw test. Eur J Pharmacol. 1984 Apr 20;100(2):239-41. PubMed PMID: 6539706. 20: Kovács GL, Szontágh L, Baláspiri L, Telegdy G. Dipeptides delay the onset of morphine withdrawal in the mouse. Acta Physiol Hung. 1984;63(1):83-4. PubMed PMID: 6540034.