N-Benzyloxycarbonylglycine
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341045

CAS#: 1138-80-3

Description: N-Benzyloxycarbonylglycine


Price and Availability

Size Price Shipping out time Quantity
5g USD 190 2 Weeks
25g USD 305 2 Weeks
100g USD 490 2 Weeks
500g USD 750 2 Weeks
1kg USD 1000 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-03. Prices are subject to change without notice.

N-Benzyloxycarbonylglycine, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 341045
Name: N-Benzyloxycarbonylglycine
CAS#: 1138-80-3
Chemical Formula: C10H11NO4
Exact Mass: 209.0688
Molecular Weight: 209.201
Elemental Analysis: C, 57.41; H, 5.30; N, 6.70; O, 30.59


Synonym: N-Benzyloxycarbonylglycine; Carbobenzoxyglycine; N-Carbobenzoxyglycine

IUPAC/Chemical Name: N-Carbobenzoxyglycine

InChi Key: CJUMAFVKTCBCJK-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H11NO4/c12-9(13)6-11-10(14)15-7-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13)

SMILES Code: c1(COC(NCC(O)=O)=O)ccccc1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Fiammengo R, Licini G, Nicotra A, Modena G, Pasquato L, Scrimin P, Broxterman QB, Kaptein B. Duality of mechanism in the tetramethylfluoroformamidinium hexafluorophosphate-mediated synthesis of N-benzyloxycarbonylamino acid fluorides. J Org Chem. 2001 Aug 24;66(17):5905-10. PubMed PMID: 11511270.

2: Lambert DM. Rationale and applications of lipids as prodrug carriers. Eur J Pharm Sci. 2000 Oct;11 Suppl 2:S15-27. Review. PubMed PMID: 11033424.

3: Scriba GK, Lambert DM. Synthesis and anticonvulsant activity of N-benzyloxycarbonyl-amino acid prodrugs of phenytoin. J Pharm Pharmacol. 1999 May;51(5):549-53. PubMed PMID: 10411214.

4: Sussan S, Dagan A, Bialer M. Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives. Epilepsy Res. 1999 Jan;33(1):11-21. PubMed PMID: 10022362.

5: Lambert DM, Geurts M, Scriba GK, Poupaert JH, Dumont P. [Simple derivatives of amino acid neurotransmitters. Anticonvulsant evaluation of derived amides, carbamates and esters of glycine and beta-alanine]. J Pharm Belg. 1995 Mar-Jun;50(2-3):194-203. French. PubMed PMID: 7674119.

6: Lambert DM. [Simple glycine derivatives from lipid transporter systems of glycine. Carrier test of a small-size neutral acid amine to the central nervous system]. Bull Mem Acad R Med Belg. 1995;150(7-9):294-300. French. PubMed PMID: 8688842.

7: Lambert DM, Poupaert JH, Maloteaux JM, Dumont P. Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration. Neuroreport. 1994 Mar 21;5(7):777-80. PubMed PMID: 8018849.

8: Bundgaard H, Rasmussen GJ. Prodrugs of peptides. 11. Chemical and enzymatic hydrolysis kinetics of N-acyloxymethyl derivatives of a peptide-like bond. Pharm Res. 1991 Oct;8(10):1238-42. PubMed PMID: 1796040.

9: Ascenzi P, Aducci P, Torroni A, Amiconi G, Ballio A, Menegatti E, Guarneri M. The pH dependence of pre-steady-state and steady-state kinetics for the papain-catalyzed hydrolysis of N-alpha-carbobenzoxyglycine p-nitrophenyl ester. Biochim Biophys Acta. 1987 Apr 8;912(2):203-10. PubMed PMID: 3828360.

10: Schack P, Kaarsholm NC. Subsite differences between the active centres of papaya peptidase A and papain as revealed by affinity chromatography. Purification of papaya peptidase A by ionic-strength-dependent affinity adsorption on an immobilized peptide inhibitor of papain. Biochem J. 1984 May 1;219(3):727-33. PubMed PMID: 6378179; PubMed Central PMCID: PMC1153538.

11: Szawelski RJ, Wharton CW. Kinetic solvent isotope effects on the deacylation of specific acyl-papains. Proton inventory studies on the papain-catalysed hydrolyses of specific ester substrates: analysis of possible transition state structures. Biochem J. 1981 Dec 1;199(3):681-92. PubMed PMID: 6280675; PubMed Central PMCID: PMC1163425.

12: Yuthavong Y, Suttimool W. Rate constants of individual steps in papain-catalysed reactions. Biochim Biophys Acta. 1978 Mar 14;523(1):198-206. PubMed PMID: 629988.

13: Lowe G, Whitworth AS. A kinetic and fluorimetric investigation of papain modified at tryptophan-69 and -177 by N-bromosuccinimide. Biochem J. 1974 Aug;141(2):503-15. PubMed PMID: 4455219; PubMed Central PMCID: PMC1168105.

14: Alecio MR, Dann ML, Lowe G. The specificity of the S1' subsite of papain. Biochem J. 1974 Aug;141(2):495-501. PubMed PMID: 4455218; PubMed Central PMCID: PMC1168104.