TC-I 2014 | CAS#1221349-53-6 | TRPM8 antagonist

TC-I 2014
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562056

CAS#: 1221349-53-6

Description: TC-I 2014 is a potent TRPM8 antagonist that exhibits antiallodynic properties in pain models.

Chemical Structure

TC-I 2014

CAS# 1221349-53-6

Instruction

Theoretical Analysis

MedKoo Cat#: 562056
Name: TC-I 2014
CAS#: 1221349-53-6
Chemical Formula: C23H19F6N3O
Exact Mass: 467.14
Molecular Weight: 467.410
Elemental Analysis: C, 59.10; H, 4.10; F, 24.39; N, 8.99; O, 3.42

Price and Availability

Size	Price	Availability
50mg	USD 850	2 Weeks
100mg	USD 1450	2 Weeks
200mg	USD 2150	2 Weeks
500mg	USD 3250	2 Weeks
1g	USD 4650	2 Weeks
2g	USD 6850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: TC-I 2014; TC I 2014; TCI 2014;

IUPAC/Chemical Name: 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

InChi Key: VSMFCZZEKTVDHM-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H19F6N3O/c24-22(25,26)15-7-3-2-6-14(15)13-10-16(23(27,28)29)19-17(11-13)30-20(31-19)18-12-21(33-32-18)8-4-1-5-9-21/h2-3,6-7,10-11H,1,4-5,8-9,12H2,(H,30,31)

SMILES Code: FC(C1=CC=CC=C1C2=CC(C(F)(F)F)=C3C(N=C(C4=NOC5(CCCCC5)C4)N3)=C2)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 467.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Andoh T, Mizoguchi S, Kuraishi Y. Shakuyakukanzoto attenuates oxaliplatin-induced cold dysesthesia by inhibiting the expression of transient receptor potential melastatin 8 in mice. J Tradit Complement Med. 2016 Feb 20;7(1):30-33. doi: 10.1016/j.jtcme.2016.01.003. eCollection 2017 Jan. PubMed PMID: 28053885; PubMed Central PMCID: PMC5198822.

2: Mizoguchi S, Andoh T, Yakura T, Kuraishi Y. Involvement of c-Myc-mediated transient receptor potential melastatin 8 expression in oxaliplatin-induced cold allodynia in mice. Pharmacol Rep. 2016 Jun;68(3):645-8. doi: 10.1016/j.pharep.2016.03.001. Epub 2016 Mar 15. PubMed PMID: 27031051.

3: Ortiz S, Zulantay I, Apt W, Saavedra M, Solari A. Transferability of Trypanosoma cruzi from mixed human host infection to Triatoma infestans and from insects to axenic culture. Parasitol Int. 2015 Feb;64(1):33-6. doi: 10.1016/j.parint.2014.09.005. Epub 2014 Sep 18. PubMed PMID: 25240699.

4: Lado WE, Spanswick DC, Lewis JE, Trudeau VL. Electrophysiological characterization of male goldfish (Carassius auratus) ventral preoptic area neurons receiving olfactory inputs. Front Neurosci. 2014 Jun 30;8:185. doi: 10.3389/fnins.2014.00185. eCollection 2014. PubMed PMID: 25071430; PubMed Central PMCID: PMC4074913.

5: Nayak TK, Ramesh C, Hathaway HJ, Norenberg JP, Arterburn JB, Prossnitz ER. GPER-targeted, 99mTc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding. Mol Cancer Res. 2014 Nov;12(11):1635-43. doi: 10.1158/1541-7786.MCR-14-0289. Epub 2014 Jul 16. PubMed PMID: 25030373; PubMed Central PMCID: PMC4233156.

6: van Lier E, Carriquiry M, Meikle A. Sex steroid modulation of cortisol secretion in sheep. Animal. 2014 Jun;8(6):960-7. doi: 10.1017/S1751731114000780. Epub 2014 Apr 4. PubMed PMID: 24703387.

7: Giglio J, Dematteis S, Fernández S, Cerecetto H, Rey A. Synthesis and evaluation of a new 99mTc(I)-tricarbonyl complex bearing the 5-nitroimidazol-1-yl moiety as potential hypoxia imaging agent. J Labelled Comp Radiopharm. 2014 May 30;57(6):403-9. doi: 10.1002/jlcr.3195. Epub 2014 Apr 1. PubMed PMID: 24692093.

8: Gianferrara T, Spagnul C, Alberto R, Gasser G, Ferrari S, Pierroz V, Bergamo A, Alessio E. Towards matched pairs of porphyrin-Re(I) /(99m) Tc(I) conjugates that combine photodynamic activity with fluorescence and radio imaging. ChemMedChem. 2014 Jun;9(6):1231-7. doi: 10.1002/cmdc.201300501. Epub 2014 Feb 23. PubMed PMID: 24678041.

9: Kasten BB, Ma X, Liu H, Hayes TR, Barnes CL, Qi S, Cheng K, Bottorff SC, Slocumb WS, Wang J, Cheng Z, Benny PD. Clickable, hydrophilic ligand for fac-[M(I)(CO)3](+) (M = Re/(99m)Tc) applied in an S-functionalized α-MSH peptide. Bioconjug Chem. 2014 Mar 19;25(3):579-92. doi: 10.1021/bc5000115. Epub 2014 Feb 25. PubMed PMID: 24568284; PubMed Central PMCID: PMC3983144.

10: Ferrer MF, Pascuale CA, Gomez RM, Leguizamón MS. DTU I isolates of Trypanosoma cruzi induce upregulation of Galectin-3 in murine myocarditis and fibrosis. Parasitology. 2014 May;141(6):849-58. doi: 10.1017/S0031182013002254. Epub 2014 Feb 13. PubMed PMID: 24533969.

11: Guizani S, Malek Saied N, Picard C, Benoist E, Saidi M. Synthesis and preliminary biological evaluation of the first (99m)Tc(I)-specific semi-rigid tridentate ligand based on a click chemistry strategy. J Labelled Comp Radiopharm. 2014 Mar;57(3):158-63. doi: 10.1002/jlcr.3182. Epub 2014 Jan 14. PubMed PMID: 24425684.

12: Connell TU, Hayne DJ, Ackermann U, Tochon-Danguy HJ, White JM, Donnelly PS. Rhenium and technetium tricarbonyl complexes of 1,4-Substituted pyridyl-1,2,3-triazole bidentate 'click' ligands conjugated to a targeting RGD peptide. J Labelled Comp Radiopharm. 2014 Apr;57(4):262-9. doi: 10.1002/jlcr.3169. Epub 2013 Dec 11. PubMed PMID: 24327475.

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