Aceclidine free base
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MedKoo CAT#: 571497

CAS#: 827-61-2 (free base racemic)

Description: Aceclidine is an agent that treats glaucoma by reducing intraocular pressure.


Chemical Structure

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Aceclidine free base
CAS# 827-61-2 (free base racemic)

Theoretical Analysis

MedKoo Cat#: 571497
Name: Aceclidine free base
CAS#: 827-61-2 (free base racemic)
Chemical Formula: C9H15NO2
Exact Mass: 169.1103
Molecular Weight: 169.22
Elemental Analysis: C, 63.88; H, 8.93; N, 8.28; O, 18.91

Price and Availability

Size Price Availability Quantity
200.0mg USD 150.0 2 Weeks
500.0mg USD 250.0 2 Weeks
1.0g USD 450.0 2 Weeks
2.0g USD 750.0 2 Weeks
5.0g USD 1650.0 2 Weeks
10.0g USD 2650.0 2 Weeks
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Related CAS #: 6109-70-2 (HCl racemic)   827-61-2 (free base racemic)   59653-40-6 (R-isomer)   59653-42-8 (S-isomer)    

Synonym: Aceclidine; Glaucostat; NSC 657843; NSC-657843; NSC657843

IUPAC/Chemical Name: 1-Azabicyclo(2.2.2)octan-3-ol, acetate (ester)

InChi Key: WRJPSSPFHGNBMG-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3

SMILES Code: CC(OC1CN2CCC1CC2)=O

Appearance: liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 169.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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16: Fechner PU, Teichmann KD, Weyrauch W. Accommodative effects of aceclidine in the treatment of glaucoma. Am J Ophthalmol. 1975 Jan;79(1):104-6. PubMed PMID: 1110190.

17: Collignon J, Prijot E. [The effect of a mixture of aceclidine and adrenaline on intraocular pressure of patients showing open-angle glaucoma]. Ophthalmologica. 1970;161(4):394-401. French. PubMed PMID: 5483905.

18: Randazzo A, Nizzola F, Rossetti L, Orzalesi N, Vinciguerra P. Pharmacological management of night vision disturbances after refractive surgery Results of a randomized clinical trial. J Cataract Refract Surg. 2005 Sep;31(9):1764-72. PubMed PMID: 16246781.

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20: Zabrodskii PF, Lim VG, Shekhter MS, Kuzmin AV. Role of nicotinic and muscarinic cholinoreceptors in the realization of the cholinergic anti-inflammatory pathway during the early phase of sepsis. Bull Exp Biol Med. 2012 Sep;153(5):700-3. PubMed PMID: 23113262.