WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555150
CAS#: Unknown
Description: SSD114 is a GABAB positive allosteric modulator. SSD114 potentiated GABA-stimulated [35S]GTPγS binding to native GABAB receptors, whereas it had no effect when used alone. SSD114, a molecule with a different chemical structure compared to known GABAB PAMs, is a novel GABAB PAM with potential usefulness in the GABAB-receptor research field.
MedKoo Cat#: 555150
Name: SSD114 HCl
CAS#: Unknown
Chemical Formula: C18H21ClF3N3O
Exact Mass:
Molecular Weight: 387.8312
Elemental Analysis: C, 55.75; H, 5.46; Cl, 9.14; F, 14.70; N, 10.83; O, 4.13
Synonym: SSD114 HCl; SSD114; SSD-114; SSD 114.
IUPAC/Chemical Name: N-cyclohexyl-4-methoxy-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine hydrochloride
InChi Key: YXQSTPASDICGCA-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H20F3N3O.ClH/c1-25-16-11-15(12-7-9-13(10-8-12)18(19,20)21)23-17(24-16)22-14-5-3-2-4-6-14;/h7-11,14H,2-6H2,1H3,(H,22,23,24);1H
SMILES Code: FC(C1=CC=C(C2=CC(OC)=NC(NC3CCCCC3)=N2)C=C1)(F)F.[H]Cl
1: Porcu A, Lobina C, Giunta D, Solinas M, Mugnaini C, Castelli MP. In vitro and
in vivo pharmacological characterization of SSD114, a novel GABAB positive
allosteric modulator. Eur J Pharmacol. 2016 Nov 15;791:115-123. doi:
10.1016/j.ejphar.2016.08.032. Epub 2016 Aug 27. PubMed PMID: 27578262.