GIBH-130
new
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555149

CAS#: 1252608-59-5

Description: GIBH-130 is a neuroinflammation inhibitor. GIBH-130 exhibited comparable in vivo efficacy of cognitive impairment relief to donepezil and memantine respectively in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models at a substantially lower dose (0.25 mg/kg). Therefore, GIBH-130 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 310 Same day
50mg USD 550 Same day
100mg USD 950 Same day
200mg USD 1450 Same day
500mg USD 1950 Same day
1g USD 2950 Same day
2g USD 4250 2 weeks
5g USD 6950 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-22. Prices are subject to change without notice.

GIBH-130, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 555149
Name: GIBH-130
CAS#: 1252608-59-5
Chemical Formula: C20H20N6O
Exact Mass: 360.1699
Molecular Weight: 360.421
Elemental Analysis: C, 66.65; H, 5.59; N, 23.32; O, 4.44


Synonym: GIBH-130; GIBH 130; GIBH130.

IUPAC/Chemical Name: (4-methyl-6-phenylpyridazin-3-yl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone

InChi Key: ZTJHTEHADIHZJS-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H20N6O/c1-15-14-17(16-6-3-2-4-7-16)23-24-18(15)19(27)25-10-12-26(13-11-25)20-21-8-5-9-22-20/h2-9,14H,10-13H2,1H3

SMILES Code: O=C(C1=NN=C(C2=CC=CC=C2)C=C1C)N3CCN(C4=NC=CC=N4)CC3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Zhou W, Zhong G, Fu S, Xie H, Chi T, Li L, Rao X, Zeng S, Xu D, Wang H, Sheng
G, Ji X, Liu X, Ji X, Wu D, Zou L, Tortorella M, Zhang K, Hu W. Microglia-Based
Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective
in Alzheimer's Disease Models. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.
Epub 2016 Sep 2. PubMed PMID: 27504670.