PhTx-74 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555147

CAS#: 1227301-51-0

Description: Philanthotoxin-74, also known as PhTx-74, is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. PhTX-74 may be of potential use in studies of the neurobiological role of GluA2-containing subtypes.

Price and Availability

Size Price Shipping out time Quantity
1g USD 2250 2 Weeks
2g USD 4250 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-26. Prices are subject to change without notice.

PhTx-74 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555147
Name: PhTx-74 HCl
CAS#: 1227301-51-0
Chemical Formula: C24H44Cl2N4O3
Exact Mass:
Molecular Weight: 507.54
Elemental Analysis: C, 56.80; H, 8.74; Cl, 13.97; N, 11.04; O, 9.46

Synonym: Philanthotoxin-74 HCl; Philanthotoxin74; Philanthotoxin 74; PhTx-74; PhTx 74; PhTx74.

IUPAC/Chemical Name: (S)-N-(1-((7-((4-aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide dihydrochloride


InChi Code: InChI=1S/C24H42N4O3.2ClH/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25;;/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30);2*1H/t22-;;/m0../s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Poulsen MH, Lucas S, Strømgaard K, Kristensen AS. Evaluation of PhTX-74 as
subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol.
2014 Feb;85(2):261-8. doi: 10.1124/mol.113.089961. Epub 2013 Nov 12. PubMed PMID:

2: Jackson AC, Milstein AD, Soto D, Farrant M, Cull-Candy SG, Nicoll RA. Probing
TARP modulation of AMPA receptor conductance with polyamine toxins. J Neurosci.
2011 May 18;31(20):7511-20. doi: 10.1523/JNEUROSCI.6688-10.2011. PubMed PMID:
21593335; PubMed Central PMCID: PMC3164836.

3: Lanté F, Toledo-Salas JC, Ondrejcak T, Rowan MJ, Ulrich D. Removal of synaptic
Ca²+-permeable AMPA receptors during sleep. J Neurosci. 2011 Mar
16;31(11):3953-61. doi: 10.1523/JNEUROSCI.3210-10.2011. PubMed PMID: 21411638.

4: Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native
AMPA receptors. J Am Chem Soc. 2007 Apr 25;129(16):4902-3. Epub 2007 Mar 29.
PubMed PMID: 17391037.