WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555148

CAS#: 347174-05-4

Description: Ferrostatin-1 (Fer-1) is a lipophilic antioxidant that effectively blocks ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. Fer-1 inhibited the ROS/RNS generated under rotenone insult in SH-SY5Y cells. Fourth, we revealed the effective role of Fer-1 in ER stress mediated activation of apoptotic pathway. Finally, we reported that Fer-1 mitigated rotenone-induced α-syn aggregation.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2650 2 Weeks
2g USD 4650 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-18. Prices are subject to change without notice.

Ferrostatin-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555148
Name: Ferrostatin-1
CAS#: 347174-05-4
Chemical Formula: C15H22N2O2
Exact Mass: 262.1681
Molecular Weight: 262.353
Elemental Analysis: C, 68.67; H, 8.45; N, 10.68; O, 12.20

Synonym: Ferrostatin-1; Frer-1;

IUPAC/Chemical Name: 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester




Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Horwath MC, Bell-Horwath TR, Lescano V, Krishnan K, Merino EJ, Deepe GS Jr.
Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem.
2017 Oct 18;18(20):2069-2078. doi: 10.1002/cbic.201700105. Epub 2017 Sep 1.
PubMed PMID: 28783875.

2: Zilka O, Shah R, Li B, Friedmann Angeli JP, Griesser M, Conrad M, Pratt DA. On
the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role
of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar
22;3(3):232-243. doi: 10.1021/acscentsci.7b00028. Epub 2017 Mar 7. PubMed PMID:
28386601; PubMed Central PMCID: PMC5364454.

3: Ito K, Eguchi Y, Imagawa Y, Akai S, Mochizuki H, Tsujimoto Y. MPP+ induces
necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y
cells. Cell Death Discov. 2017 Feb 27;3:17013. doi: 10.1038/cddiscovery.2017.13.
eCollection 2017. PubMed PMID: 28250973; PubMed Central PMCID: PMC5327502.

4: Kabiraj P, Valenzuela CA, Marin JE, Ramirez DA, Mendez L, Hwang MS,
Varela-Ramirez A, Fenelon K, Narayan M, Skouta R. The neuroprotective role of
ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic
neuroblastoma cells. Protein J. 2015 Oct;34(5):349-58. doi:
10.1007/s10930-015-9629-7. PubMed PMID: 26385697.