Prucalopride hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562041

CAS#: 179474-80-7 (HCl)

Description: Prucalopride hydrochloride is a selective 5-HT4 agonist.

Chemical Structure

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Prucalopride hydrochloride
CAS# 179474-80-7 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 562041
Name: Prucalopride hydrochloride
CAS#: 179474-80-7 (HCl)
Chemical Formula: C18H27Cl2N3O3
Exact Mass: 403.14
Molecular Weight: 404.330
Elemental Analysis: C, 53.47; H, 6.73; Cl, 17.54; N, 10.39; O, 11.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Related CAS #: 179474-85-2 (Succinate)   179474-81-8 (free base)   179474-80-7 (HCl)    

Synonym: R-108512; R 108512; R108512; R 093877; R-093877; R093877; R 93877; R-93877; R93877; Prucalopride hydrochloride; Prucalopride HCl; Motegrity; Resolor; Resotran;

IUPAC/Chemical Name: 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide hydrochloride

InChi Key: KKMOQGWTJRGLNN-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H26ClN3O3.ClH/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;/h11-12H,2-10,20H2,1H3,(H,21,23);1H

SMILES Code: O=C(C1=CC(Cl)=C(N)C2=C1OCC2)NC3CCN(CCCOC)CC3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 404.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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14: Retraction: "Chronic constipation-associated symptoms in Asians and non-Asians, and effects of 12-week prucalopride treatment: A pooled analysis of 4 randomized, placebo-controlled trials" by Suck Chei CHOI, Duo Wu ZOU, Mei Yun KE, Somchai LEELAKUSOLVONG, Jan TACK, Eamonn MM QUIGLEY, Andy LIU and Jin Yong KIM. J Dig Dis. 2016 Apr;17(4):277. doi: 10.1111/1751-2980.12219. Review. PubMed PMID: 25495559.

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17: Keating GM. Prucalopride: a review of its use in the management of chronic constipation. Drugs. 2013 Nov;73(17):1935-50. doi: 10.1007/s40265-013-0140-1. Review. PubMed PMID: 24194435.

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19: Pennant M, Orlando R, Barton P, Bayliss S, Routh K, Meads C. Prucalopride for the treatment of women with chronic constipation in whom standard laxative regimens have failed to provide adequate relief. Health Technol Assess. 2011 May;15 Suppl 1:43-50. doi: 10.3310/hta15suppl1/05. Review. PubMed PMID: 21609652.

20: What role for prucalopride in constipation? Drug Ther Bull. 2011 Aug;49(8):93-6. doi: 10.1136/dtb.2011.02.0050. Review. PubMed PMID: 21831905.