HEMADO | CAS#403842-38-6 | A3 receptor agonist

HEMADO
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527760

CAS#: 403842-38-6

Description: HEMADO is a potent and selective adenosine A3 receptor agonist.

Chemical Structure

HEMADO

CAS# 403842-38-6

Instruction

Theoretical Analysis

MedKoo Cat#: 527760
Name: HEMADO
CAS#: 403842-38-6
Chemical Formula: C17H23N5O4
Exact Mass: 361.18
Molecular Weight: 361.402
Elemental Analysis: C, 56.50; H, 6.42; N, 19.38; O, 17.71

Price and Availability

Size	Price	Availability
5mg	USD 350	2 Weeks
10mg	USD 600	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: HEMADO

IUPAC/Chemical Name: 2-(1-Hexynyl)-N-methyladenosine

InChi Key: KOCIMZNSNPOGOP-IWCJZZDYSA-N

InChi Code: InChI=1S/C17H23N5O4/c1-3-4-5-6-7-11-20-15(18-2)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,3-5,8H2,1-2H3,(H,18,20,21)/t10-,13-,14-,17-/m1/s1

SMILES Code: OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=C(C#CCCCC)N=C32)NC)O1)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 361.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stoddart LA, Kellam B, Briddon SJ, Hill SJ. Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. Br J Pharmacol. 2014 Aug;171(16):3827-44. doi: 10.1111/bph.12739. PubMed PMID: 24750014; PubMed Central PMCID: PMC4128046.

2: Dal Ben D, Buccioni M, Lambertucci C, Kachler S, Falgner N, Marucci G, Thomas A, Cristalli G, Volpini R, Klotz KN. Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch. Biochem Pharmacol. 2014 Jan 15;87(2):321-31. doi: 10.1016/j.bcp.2013.10.011. Epub 2013 Oct 23. PubMed PMID: 24161786.

3: Amani M, Jeddi S, Ahmadiasl N, Usefzade N, Zaman J. Effect of HEMADO on Level of CK-MB and LDH Enzymes after Ischemia/Reperfusion Injury in Isolated Rat Heart. Bioimpacts. 2013;3(2):101-4. doi: 10.5681/bi.2013.003. Epub 2012 Nov 13. PubMed PMID: 23878794; PubMed Central PMCID: PMC3713869.

4: Yuan K, Bai GY, Park WH, Kim SZ, Kim SH. Stimulation of ANP secretion by 2-Cl-IB-MECA through A(3) receptor and CaMKII. Peptides. 2008 Dec;29(12):2216-24. doi: 10.1016/j.peptides.2008.09.003. Epub 2008 Sep 16. PubMed PMID: 18838091.

5: Klotz KN, Falgner N, Kachler S, Lambertucci C, Vittori S, Volpini R, Cristalli G. [3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. Epub 2006 Oct 27. PubMed PMID: 17126322.

6: Ravyn V, Bostwick JR. Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor. J Recept Signal Transduct Res. 2006;26(4):241-58. PubMed PMID: 16818375.

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