Nylidrin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584297

CAS#: 447-41-6

Description: Nylidrin is a beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.


Price and Availability

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Nylidrin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584297
Name: Nylidrin
CAS#: 447-41-6
Chemical Formula: C19H25NO2
Exact Mass: 299.1885
Molecular Weight: 299.414
Elemental Analysis: C, 76.22; H, 8.42; N, 4.68; O, 10.69


Synonym: Nylidrin; Buphenine

IUPAC/Chemical Name: Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-

InChi Key: PTGXAUBQBSGPKF-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25NO2/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17/h3-7,10-15,19-22H,8-9H2,1-2H3

SMILES Code: OC(C(NC(C)CCC1=CC=CC=C1)C)C2=CC=C(O)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Sharma JK, Gupta AK, Mukhija RD, Nigam P. Clinical experience with the use of peripheral vasodilator in oral disorders. Int J Oral Maxillofac Surg. 1987 Dec;16(6):695-9. PubMed PMID: 3125268.

2: Accetto B. Beneficial hemorheologic therapy of chronic peripheral arterial disorders with pentoxifylline: results of double-blind study versus vasodilator-nylidrin. Am Heart J. 1982 May;103(5):864-9. PubMed PMID: 7041579.

3: Salokorpi T, Eronen M, von Wendt L. Growth and development until 18 months of children exposed to tocolytics indomethacin or nylidrin. Neuropediatrics. 1996 Aug;27(4):174-7. PubMed PMID: 8892364.

4: Mittag TW, Tormay A, Messenger M, Podos SM. Ocular hypotension in the rabbit. Receptor mechanisms of pirbuterol and nylidrin. Invest Ophthalmol Vis Sci. 1985 Feb;26(2):163-9. PubMed PMID: 2857689.

5: Whittemore ER, Ilyin VI, Konkoy CS, Woodward RM. Subtype-selective antagonism of NMDA receptors by nylidrin. Eur J Pharmacol. 1997 Oct 22;337(2-3):197-208. PubMed PMID: 9430414.

6: Yen TT, Pearson DV. Nylidrin: a potent anti-hypertensive agent in hypertensive rats. Res Commun Chem Pathol Pharmacol. 1979 Jan;23(1):11-28. PubMed PMID: 441505.

7: Kurki T, Viinikka L, Ylikorkala O. Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):150-4. PubMed PMID: 1733190.

8: Kurki T, Eronen M, Lumme R, Ylikorkala O. A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. Obstet Gynecol. 1991 Dec;78(6):1093-7. PubMed PMID: 1945214.

9: Kurki T, Laatikainen T, Salminen-Lappalainen K, Ylikorkala O. Maternal plasma corticotrophin-releasing hormone--elevated in preterm labour but unaffected by indomethacin or nylidrin. Br J Obstet Gynaecol. 1991 Jul;98(7):685-91. PubMed PMID: 1883793.

10: Niemeyer G, Cottier D, Gerber U. Effects of beta-agonists on b- and c-waves implicit for adrenergic mechanisms in cat retina. Doc Ophthalmol. 1987 Aug;66(4):373-81. PubMed PMID: 2892656.

11: Uji Y, Niemeyer G, Gerber U. The effects of beta-adrenergic agonists on cone systems in the cat eye. Doc Ophthalmol. 1988 Sep;70(1):77-87. PubMed PMID: 3229296.

12: Daly MJ, Long JM, Stables R. The effects of (--)-isoprenaline, salbutamol and nylidrin on gastric acid secretion in conscious dogs with Heidenhain pouches [proceedings]. Br J Pharmacol. 1978 Jun;63(2):376P-377P. PubMed PMID: 667456; PubMed Central PMCID: PMC1668395.

13: Abel PW, Fox AW, Minneman KP. Effects of isoxuprine and nylidrin on adrenoreceptors in rat vas deferens. J Auton Pharmacol. 1985 Sep;5(3):213-9. PubMed PMID: 2997229.

14: Sobel L, Serle JB, Podos SM, Krupin T, Chubak GS, Yablonski ME, Severin C. Topical nylidrin and aqueous humor dynamics in rabbits and monkeys. Arch Ophthalmol. 1983 Aug;101(8):1281-3. PubMed PMID: 6882258.

15: KIKUNI M, HAYATSU H. [Effects of nylidrin hydrochloride (verina) upon retinal blood vessels]. Rinsho Ganka. 1962 Jan 15;16:75-80. Japanese. PubMed PMID: 14455897.

16: TREPTOW KR, AFFLECK DC, ROEHL CA, SOELLING WM. NYLIDRIN HYDROCHLORIDE IN SENILE ARTERIOSCLEROSIS. Arch Neurol. 1963 Aug;9:142-6. PubMed PMID: 14054151.

17: Pahk AJ, Williams K. Influence of extracellular pH on inhibition by ifenprodil at N-methyl-D-aspartate receptors in Xenopus oocytes. Neurosci Lett. 1997 Mar 28;225(1):29-32. PubMed PMID: 9143010.

18: TAKAO H, KIMURA M, NORII T. [CLINICAL EFFECTIVENESS OF VERINA (NYLIDRIN HYDROCHLORIDE)]. Chiryo. 1963;45:2268-70. Japanese. PubMed PMID: 14103596.

19: Montijo-Barrios E, Cadena F, Ramírez-Mayans JA, Gutiérrez-Castrellón P. [Clinical trial on the effect of buphenine, aminophenazone and diphenylpyraline hydrochloride in treating the common cold in children of 6 to 24 months of age]. Rev Invest Clin. 2011 Jul-Aug;63(4):335-43. Spanish. PubMed PMID: 22364032.

20: Coutts SM, Khandwala A, Weinryb I. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). II. A lack of correlation between inhibition of mediator release and levels of cyclic AMP. Int Arch Allergy Appl Immunol. 1983;70(4):303-10. PubMed PMID: 6186609.