Nylidrin
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MedKoo CAT#: 584297

CAS#: 447-41-6

Description: Nylidrin is a beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.


Chemical Structure

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Nylidrin
CAS# 447-41-6

Theoretical Analysis

MedKoo Cat#: 584297
Name: Nylidrin
CAS#: 447-41-6
Chemical Formula: C19H25NO2
Exact Mass: 299.1885
Molecular Weight: 299.414
Elemental Analysis: C, 76.22; H, 8.42; N, 4.68; O, 10.69

Price and Availability

Size Price Availability Quantity
5.0mg USD 210.0 2 Weeks
10.0mg USD 340.0 2 Weeks
25.0mg USD 540.0 2 Weeks
50.0mg USD 810.0 2 Weeks
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Synonym: Nylidrin; Buphenine;

IUPAC/Chemical Name: Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-

InChi Key: PTGXAUBQBSGPKF-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25NO2/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17/h3-7,10-15,19-22H,8-9H2,1-2H3

SMILES Code: OC(C(NC(C)CCC1=CC=CC=C1)C)C2=CC=C(O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 299.414 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sharma JK, Gupta AK, Mukhija RD, Nigam P. Clinical experience with the use of peripheral vasodilator in oral disorders. Int J Oral Maxillofac Surg. 1987 Dec;16(6):695-9. PubMed PMID: 3125268.

2: Accetto B. Beneficial hemorheologic therapy of chronic peripheral arterial disorders with pentoxifylline: results of double-blind study versus vasodilator-nylidrin. Am Heart J. 1982 May;103(5):864-9. PubMed PMID: 7041579.

3: Salokorpi T, Eronen M, von Wendt L. Growth and development until 18 months of children exposed to tocolytics indomethacin or nylidrin. Neuropediatrics. 1996 Aug;27(4):174-7. PubMed PMID: 8892364.

4: Mittag TW, Tormay A, Messenger M, Podos SM. Ocular hypotension in the rabbit. Receptor mechanisms of pirbuterol and nylidrin. Invest Ophthalmol Vis Sci. 1985 Feb;26(2):163-9. PubMed PMID: 2857689.

5: Whittemore ER, Ilyin VI, Konkoy CS, Woodward RM. Subtype-selective antagonism of NMDA receptors by nylidrin. Eur J Pharmacol. 1997 Oct 22;337(2-3):197-208. PubMed PMID: 9430414.

6: Yen TT, Pearson DV. Nylidrin: a potent anti-hypertensive agent in hypertensive rats. Res Commun Chem Pathol Pharmacol. 1979 Jan;23(1):11-28. PubMed PMID: 441505.

7: Kurki T, Viinikka L, Ylikorkala O. Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):150-4. PubMed PMID: 1733190.

8: Kurki T, Eronen M, Lumme R, Ylikorkala O. A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. Obstet Gynecol. 1991 Dec;78(6):1093-7. PubMed PMID: 1945214.

9: Kurki T, Laatikainen T, Salminen-Lappalainen K, Ylikorkala O. Maternal plasma corticotrophin-releasing hormone--elevated in preterm labour but unaffected by indomethacin or nylidrin. Br J Obstet Gynaecol. 1991 Jul;98(7):685-91. PubMed PMID: 1883793.

10: Niemeyer G, Cottier D, Gerber U. Effects of beta-agonists on b- and c-waves implicit for adrenergic mechanisms in cat retina. Doc Ophthalmol. 1987 Aug;66(4):373-81. PubMed PMID: 2892656.

11: Uji Y, Niemeyer G, Gerber U. The effects of beta-adrenergic agonists on cone systems in the cat eye. Doc Ophthalmol. 1988 Sep;70(1):77-87. PubMed PMID: 3229296.

12: Daly MJ, Long JM, Stables R. The effects of (--)-isoprenaline, salbutamol and nylidrin on gastric acid secretion in conscious dogs with Heidenhain pouches [proceedings]. Br J Pharmacol. 1978 Jun;63(2):376P-377P. PubMed PMID: 667456; PubMed Central PMCID: PMC1668395.

13: Abel PW, Fox AW, Minneman KP. Effects of isoxuprine and nylidrin on adrenoreceptors in rat vas deferens. J Auton Pharmacol. 1985 Sep;5(3):213-9. PubMed PMID: 2997229.

14: Sobel L, Serle JB, Podos SM, Krupin T, Chubak GS, Yablonski ME, Severin C. Topical nylidrin and aqueous humor dynamics in rabbits and monkeys. Arch Ophthalmol. 1983 Aug;101(8):1281-3. PubMed PMID: 6882258.

15: KIKUNI M, HAYATSU H. [Effects of nylidrin hydrochloride (verina) upon retinal blood vessels]. Rinsho Ganka. 1962 Jan 15;16:75-80. Japanese. PubMed PMID: 14455897.

16: TREPTOW KR, AFFLECK DC, ROEHL CA, SOELLING WM. NYLIDRIN HYDROCHLORIDE IN SENILE ARTERIOSCLEROSIS. Arch Neurol. 1963 Aug;9:142-6. PubMed PMID: 14054151.

17: Pahk AJ, Williams K. Influence of extracellular pH on inhibition by ifenprodil at N-methyl-D-aspartate receptors in Xenopus oocytes. Neurosci Lett. 1997 Mar 28;225(1):29-32. PubMed PMID: 9143010.

18: TAKAO H, KIMURA M, NORII T. [CLINICAL EFFECTIVENESS OF VERINA (NYLIDRIN HYDROCHLORIDE)]. Chiryo. 1963;45:2268-70. Japanese. PubMed PMID: 14103596.

19: Montijo-Barrios E, Cadena F, Ramírez-Mayans JA, Gutiérrez-Castrellón P. [Clinical trial on the effect of buphenine, aminophenazone and diphenylpyraline hydrochloride in treating the common cold in children of 6 to 24 months of age]. Rev Invest Clin. 2011 Jul-Aug;63(4):335-43. Spanish. PubMed PMID: 22364032.

20: Coutts SM, Khandwala A, Weinryb I. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). II. A lack of correlation between inhibition of mediator release and levels of cyclic AMP. Int Arch Allergy Appl Immunol. 1983;70(4):303-10. PubMed PMID: 6186609.