Idrocilamide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584273

CAS#: 6961-46-2

Description: Idrocilamide, also known as Brolitene, exhibits anti inflammatory and muscle relaxant properties.


Chemical Structure

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Idrocilamide
CAS# 6961-46-2

Theoretical Analysis

MedKoo Cat#: 584273
Name: Idrocilamide
CAS#: 6961-46-2
Chemical Formula: C11H13NO2
Exact Mass: 191.0946
Molecular Weight: 191.23
Elemental Analysis: C, 69.09; H, 6.85; N, 7.32; O, 16.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Idrocilamide; Brolitene

IUPAC/Chemical Name: 2-Propenamide, N-(2-hydroxyethyl)-3-phenyl-

InChi Key: OSCTXCOERRNGLW-VOTSOKGWSA-N

InChi Code: InChI=1S/C11H13NO2/c13-9-8-12-11(14)7-6-10-4-2-1-3-5-10/h1-7,13H,8-9H2,(H,12,14)/b7-6+

SMILES Code: O=C(NCCO)/C=C/C1=CC=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 191.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Lery N, Evreux JC, Schwam E, Laisne H. [Letter: Unusual neuropsychic effects due to idrocilamide]. Nouv Presse Med. 1976 Feb 28;5(9):583-4. French. PubMed PMID: 1264724.

2: Bannwarth B, Le Huec JC, Vinçon G, Labat L, Demotes-Mainard F, Rivaille F, Le Rebeller A. [Tissue and systemic diffusion of idrocilamide after cutaneous administration]. Rev Rhum Ed Fr. 1993 Dec;60(12):932-6. French. PubMed PMID: 8012322.

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6: Bouron A, Rivet M, Nasri-Sebdani M, Guillemain J, Durbin P, Guerrier D, Raymond G. The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers. Can J Physiol Pharmacol. 1990 Dec;68(12):1503-9. PubMed PMID: 2085796.

7: Tarrús E, García I, Roberts DJ, Segura J. An animal model for the detection of drug-induced inhibition of caffeine metabolism. Methods Find Exp Clin Pharmacol. 1987 May;9(5):311-6. PubMed PMID: 3613760.

8: Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC. Inhibition by idrocilamide of the disposition of caffeine. Eur J Clin Pharmacol. 1980 Jan;17(1):37-43. PubMed PMID: 7371698.

9: Stehman M, Lehert P. [Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago]. Acta Belg Med Phys. 1990 Jan-Mar;13(1):29-32. Dutch, French. PubMed PMID: 2140002.

10: Maier-Lenz H, Ringwelski L, Windorfer A. [Pharmacokinetics and bioavailability of the myotonolytic N-(hydroxy-2-ethyl)-cinnamide (author's transl)]. Arzneimittelforschung. 1980;30(10):1813-6. German. PubMed PMID: 7192119.

11: Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet. 2000 Aug;39(2):127-53. Review. PubMed PMID: 10976659.

12: Upton RA. Pharmacokinetic interactions between theophylline and other medication (Part I). Clin Pharmacokinet. 1991 Jan;20(1):66-80. Review. PubMed PMID: 1674242.

13: Perkin GD, Aminoff MJ. A trial of brolitene in the treatment of spasticity. Br J Clin Pharmacol. 1976 Oct;3(5):879-82. PubMed PMID: 788760; PubMed Central PMCID: PMC1428935.

14: Delwaide PJ. Electrophysiological analysis of the mode of action of muscle relaxants in spasticity. Ann Neurol. 1985 Jan;17(1):90-5. PubMed PMID: 3985591.

15: André P, Descotes J, Simonet R, Evreux JC. Reappraisal of the barbiturate sleeping time in mice as predictive tool for the detection of liver enzymes inhibiting drugs. Methods Find Exp Clin Pharmacol. 1984 Nov;6(11):695-9. PubMed PMID: 6530908.